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Director Protein Affinity Reagent Discovery

Nautilus Biotechnology
San Carlos, CA Full Time
POSTED ON 9/21/2021 CLOSED ON 2/17/2022

What are the responsibilities and job description for the Director Protein Affinity Reagent Discovery position at Nautilus Biotechnology?

Nautilus is building a high-throughput pipeline for generating a large number of antibodies and related affinity reagents for use in our proteomics platform. These molecules will include canonical protein- or protein-isoform specific molecules, as well as multi-affinity probes which are the heart of our novel proteomics platform.  Unlike traditional affinity reagent discovery challenges that are focused on optimizing towards a single-best affinity reagent to a single-target, we are instead more target agnostic, but interested in developing a large catalog of hundreds of reagents against a wide range of epitopes.   We are looking for an experienced, hands-on scientific leader and scientific expert to lead a team developing and applying a high-throughput workflow for discovering lead candidate molecules.  Methods for discovering candidates will include a mix of molecular evolution (e.g Phage Display) and knowledge-based (e.g. in silico design) workflows.    Building a new team at the center of Nautilus’ novel platform, this key role will help drive the creation of a high throughput pipeline for developing the core reagents enabling Nautilus’ ability to decode the full proteome
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