What are the responsibilities and job description for the Sr. Principal Scientist, Antibody Engineering position at Neurocrine Bioscience?
Who We Are :
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At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.
What We Do :
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose : to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders.
About the Role :
The Sr. Principal Scientist, Antibody Engineering will lead laboratory activities related to antibody engineering including cloning, mutagenesis, library construction, and variant affinity screening. The ideal candidate will have extensive hands-on experience and a proven track record in therapeutic antibody optimization, in a biotechnology or pharmaceutical company setting. The person in this role will support protein engineering in all areas of early-mid stage antibody optimization for Neurocrine’s biotherapeutic pipeline.
Your Contributions (include, but are not limited to) :
- Neurocrine is expanding its team of talented scientists with proven track records, to drive therapeutic pipeline progression from discovery to lead selection within a cutting-edge antibody engineering team.
- We are seeking a lead protein engineer responsible for construct design, molecular cloning, multi-piece DNA assembly, site-directed mutagenesis, and preparation of libraries.
- Responsibilities include generating and screening site-directed, CDR randomization and combinatorial antibody libraries for affinity maturation and developability optimization.
- A critical member of the team contributing to characterizing antibodies and antibody-based therapeutics (e.g. affinity, specificity, cross-species binding, epitope determination).
- Will be involved in the engineering of advanced modalities such as multi-specific antibodies and antibody conjugates.
- Contribute to the design and cloning of antigens.
- Responsible for understanding experimental data from multiple sources, forming hypotheses, devising strategies, and implementing prioritization to drive projects.
- Contribute to the evaluation of emerging molecular biological or biochemical methods, initiate and support new platforms, instrumentation, and technologies for antibody engineering.
- Working cross-functionally with protein biochemists, cell biologists, and gene therapists to achieve project goals.
- Other duties as assigned.
Requirements :
Neurocrine Biosciences is an EEO / AA / Disability / Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.
The annual base salary we reasonably expect to pay is $106,400.00-$154,325.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties / requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver / parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
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Salary : $106,400 - $154,325