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Scientist/Sr. Scientist, Bioanalytical

Neurocrine Biosciences
San Diego, CA Full Time
POSTED ON 1/23/2025
AVAILABLE BEFORE 4/22/2025

Who We Are :

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

What We Do :

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose : to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis

  • and uterine fibroids
  • as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (
  • in collaboration with AbbVie)

About the Role :

As a member of the Drug Metabolism and Pharmacokinetics (DMPK) team, the bioanalytical Scientist / Sr. Scientist will be responsible for developing, optimizing, and implementing LC-MS bioanalytical methods to support the quantitative analysis of various drug candidates and modalities (small molecules, peptides, and proteins) in preclinical in vivo studies. Will support quantitative evaluation of new products and maintenance of current pipeline through the application of pharmacokinetic data analysis (i.e., NCA) and PK / PD modeling and analysis. This position also involves working collaboratively with cross-functional teams within DMPK as well as R&D to support drug discovery and development programs.

Your Contributions (include, but are not limited to) :

Develop and execute LC-MS / MS bioanalytical methods for the quantification of small molecules, peptides, and proteins in biological samples from in-vivo pharmacokinetic, pharmacology and toxicology studies

May develop and implement novel LC-MS / MS and LC-HRMS methodologies to analyze drug candidates

May develop LC-HRMS methods for metabolite identification of protein therapeutics

May act as a bioanalytical representative on discovery or development teams

May manage outsourcing of BA / PK / TK studies with external CRO partners

May contribute to the preparation or review of regulatory submissions and study reports

May mentor or train less experienced team members

Requirements :

  • BS / BA degree in Chemistry or closely related field and 5 years of industry experience in an biotech, pharma, and / or CRO setting; Experience working in and accomplishing tasks a timeline driven setting; Experience in lab automation is required; Experience in large molecules and biomarkers bioanalysis is preferred OR
  • MS / MA degree in Chemistry or closely related field and 3 years of similar experience noted above OR
  • PhD or equivalent and some similar experience as noted above or PostDoc work
  • Strong background in bioanalytical job-relevant core competency (instrumental analysis (LC / MS / MS and / or LC / UV), automation, matrix analysis, specialty mass spectrometry techniques, method development / qualification / validation)
  • Strong expertise in LC-MS / MS method development, optimization and troubleshooting on Triple Quadrupole (Sciex or similar) and / or Orbitrap HRMS
  • Proficiency in sample preparation techniques for biological matrices, such as solid-phase extraction, protein precipitation and affinity purification
  • Extensive hands-on experience with role-appropriate technology and methodology such as : automation, LC-MS / MS, PK analysis and modeling and simulation software
  • Experience in LC-HRMS for biotransformation / metabolism of protein therapeutics is desirable
  • Strong written and verbal communication skills
  • Demonstrates solid level of understanding project / group goals and methods
  • Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes
  • Able to explain the process behind the data and implications of the results
  • Strong knowledge of one or more scientific disciplines, becoming expert in one discipline
  • Strong knowledge of scientific principles, methods and techniques
  • Strong knowledge and demonstrated ability working with a variety of laboratory instrumentation and / or PK analysis and or modeling and simulation software
  • Ability to work as part of a team; may train lower levels
  • Excellent computer skills
  • Strong problem-solving, analytical thinking skills
  • Detail oriented and developing understanding of scientific impact on broader team objectives
  • Ability to meet multiple deadlines, with a high degree of accuracy and efficiency
  • LI-DM1

    Neurocrine Biosciences is an EEO / AA / Disability / Vets employer.

    We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

    The annual base salary we reasonably expect to pay is $108,600.00-$157,350.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties / requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver / parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

    Salary : $108,600 - $157,350

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