What are the responsibilities and job description for the Sr. Scientist, Biologics Research position at Neurocrine Biosciences?
Who We Are :
At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.
What We Do :
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose : to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis
- and uterine fibroids,
- as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (
- in collaboration with AbbVie)
About the Role :
Neurocrine is building a team of talented scientists with proven track records to drive biotherapeutic lead selection and pipeline progression of our cutting-edge antibody programs into the clinic. We are seeking a cell biologist responsible for establishing stable CHO cell line development capability to support production of antibodies and other protein therapeutic agents.
The Senior Scientist, Cell Line Development will lead the establishment of cell line development capability, including workspace design, planning and conduct of laboratory activities related to creating stable CHO cell lines and characterizing their titer, product quality profile and stability. The ideal candidate will have hands-on experience with expression vector construction, transfection and expansion of stable CHO pools and clonal selection of CHO cell lines in a biotechnology or pharmaceutical company setting.
Your Contributions (include, but are not limited to) :
Set up cell line development processes and procedures
Carry out stable CHO transfections on antibody and bispecific programs
Design and carry out studies to optimize signal peptides and / or ratios for multiple chains
Expand stable CHO pools for protein expression purposes
Carry out clonal selection, fed batch evaluation, partnering with team members to evaluate titer, product quality attributes and assess cell line stability
Maintain appropriate documentation and prepare reports in support of regulatory filings
Serve as subject matter expert in interactions with CDMOs
Other duties as assigned
Requirements :
BS / BA degree and 4 years of relevant experience OR
MS / MA degree and 3 years of relevant experience OR
PhD or equivalent and some relevant experience in mammalian cell line development may include postdoc experience
Expert knowledge of molecular cloning, CHO expression vector construction and sequence analysis
In-depth knowledge of intellectual property landscape of host cell line and expression technology
Expert knowledge of mammalian protein expression technology and bispecific antibody cell line development
Extensive experience in creation, maintenance and characterization of clonal CHO cell lines from single cell cloning to RCB including selection of a final clone
Familiarity with therapeutic protein product quality metrics
Familiarity with CMC and regulatory requirements
Strong documentation management skills
Hands on experience with above and willingness to work in the lab
Expertise in laboratory operations, including budgeting, capex procurement and IQ / OQ, safety, and status reporting to Senior Management
Experience with biologics upstream process development a plus
Demonstrates solid level of understanding project / group goals and methods
Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes
Able to explain the process behind the data and implications of the results
Strong knowledge of one or more scientific disciplines, becoming expert in one discipline
Strong knowledge of scientific principles, methods and techniques
Strong knowledge and demonstrated ability working with a variety of laboratory equipment / tools
Good statistical skills; hands-on experience with DOE study design and statistical analysis
Ability to work as part of a team; may train lower levels
Excellent computer skills
Strong communications, problem-solving, analytical thinking skills
Detail oriented yet can see broader picture of scientific impact on team
Ability to meet multiple deadlines, with a high degree of accuracy and efficiency
Strong project management skills to support and prioritize multiple projects
LI-OB1
Neurocrine Biosciences is an EEO / AA / Disability / Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.
The annual base salary we reasonably expect to pay is $108,600.00-$157,350.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties / requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver / parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
Salary : $108,600 - $157,350
