What are the responsibilities and job description for the Sr. Principal Scientist to Associate Director, Translational Modeling & Simulation position at Novartis Group Companies?
Job Description Summary
LI-Hybrid
About the role :
Novartis is a leader in the cardiovascular / renal and neuroscience disease areas with a robust pipeline of projects. We are seeking a translational modeler eager to accelerate projects with emerging and traditional modalities, including siRNA therapeutics ("xRNA"), antibodies and antibody conjugates, and small molecules. You will work in a multi-disciplinary environment with early discovery teams to inform lead optimization strategy and preclinical teams to drive compounds from candidate selection to first-in-human. As part of a truly translational modeling team, you will also collaborate with clinical pharmacology and pharmacometrics groups to leverage quantitative systems pharmacology (QSP) approaches to inform clinical decisions spanning early dose optimization to life-cycle management.
This role reports to a PK Sciences Translational M&S team lead, in a group situated within Biomedical Research, the research engine of Novartis.
Job Description
Key Responsibilities :
- Act as the Translational M&S representative on several programs. Develop and execute modeling strategies, contribute to project team discussions, and guide decisions from therapeutic design to first-in-human dose selection and beyond.
- Build and apply PK / PD, QSP, and physiologically-based PK (PBPK) models that link drug pharmacology, tissue biodistribution, mechanism(s) of action, and biological outcomes.
- Collaboratively develop platform models and modeling workflows that extend across multiple projects and phases of discovery & development.
- Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences.
- Engage in strategic initiatives within M&S, such as coordinating modeling activities for a disease area or therapeutic modality or leading the development of a new platform. Contribute as a scientific area expert across PK Sciences and Biomedical Research.
Essential requirements :
Desirable Requirements :
Experience modeling in cardiovascular, renal, and / or neuroscience disease areas is preferred
Experience with RNA therapeutics (siRNA, ASO), antibodies, antibody-drug conjugates (ADCs), and / or low molecular weight compounds is strongly preferred.
This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
ModelingAndSimulation #PKSciences
Commitment to Diversity and Inclusion / EEO : The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Novartis Compensation and Benefit Summary : The pay range for this position at commencement of employment is expected to be between $152,600 to $283,400 / year; however, while salary ranges are effective from 1 / 1 / 25 through 12 / 31 / 25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and / or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department / team performance, and market factors.
EEO Statement :
The Novartis Group of Companies are Equal Opportunity Employers who are focused on building and advancing a culture of inclusion that values and celebrates individual differences, uniqueness, backgrounds and perspectives. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to fostering a diverse and inclusive workplace that reflects the world around us and connects us to the patients, customers and communities we serve.
Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call 1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Salary Range
152,600.00 - $283,400.00
Skills Desired
Algorithms, Clinical Trials, Cross-Functional Teams, Data Engineering, Decision Making Skills, Innovation, Mentorship, Modeling And Simulation, Simulation Software, Waterfall Model
Salary : $152,600 - $283,400
