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Scientist I – Bioconjugate Chemist (Contractor) – Discovery Chemistry

Nurix Therapeutics
San Francisco, CA Full Time
POSTED ON 4/9/2025
AVAILABLE BEFORE 5/8/2025

Position

We are seeking a talented and highly motivated scientist with a strong background and hands-on experience in bioconjugation to join our Discovery Chemistry team. In this laboratory-based position, you will play a pivotal role in the development of cutting-edge Degrader-Antibody Conjugates (DACs) across various therapeutic areas. The successful candidate will have the opportunity to directly contribute to the following key platform operations :

  • Develop, optimize and implement high-throughput bioconjugation processes through the application of established and state-of-the-art technologies
  • Execute high-throughput preparation of novel antibody drug conjugates at milligram scale
  • Contribute to the design and synthesis of linkers and linker-payloads to enhance conjugate properties
  • Prepare, purity and characterize bioconjugates to support in-vitro and in-vivo studies
  • Contribute to the collaborative efforts focused on the development and optimization of bioanalytical protocols to evaluate critical quality attributes of DACs
  • Engage in cross-functional discussions and contribute to scientific strategies and team goals focused on advancing Nurix’s Degrader-Antibody Conjugate (DAC) discovery programs
  • Prepare reports and present data at internal group meetings

Education and Experience

  • Ph.D. in Organic Chemistry, Chemical Biology, Biochemistry, or related field with up to 4 years relevant experience OR MS with 6 years relevant experience, OR BS or equivalent with 10 years relevant experience
  • Experience with high-throughput automated workflows to produce bioconjugates
  • Hands-on laboratory experience in carrying out diverse conjugation chemistry protocols, linker-payload synthesis and related processors to produce high-quality drug conjugates
  • Familiar with the general workflow operations, instrumentation and practices used for the generation of antibody-drug conjugates
  • Experience characterizing and purifying bioconjugates using common analytical tools
  • Experience working in the drug discovery chemistry field – linker design, synthesis, and SAR based property optimization of small molecules
  • Established track record of conference presentations and peer-reviewed publications in the areas of antibody drug conjugation and organic synthesis
  • Strong written and verbal communication skills
  • Added Quantifications

  • Postdoctoral or industrial work experience in the bioconjugation field
  • Experience working in Antibody-Drug Conjugate (ADC)- or Degrader-Antibody Conjugate (DAC)- based drug discovery programs
  • Experience working with bioanalytical tools such as hydrophobic interaction chromatography (HIC), preparative-scale size exclusion chromatography (SEC), liquid chromatography-mass spectrometry (LC-MS), ion-exchange (IEX), and reversed phase (RP)-HPLC, Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Experience carrying our assays to evaluate in-vitro stability of ADC and payloads such as Cathepsin B, esterase activity and free drug analysis
  • Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( https : / / www.nurixtx.com / privacy-policy / ).

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