Scientist, RNA Production Research Optimization (P.R.O.)

Orna Therapeutics is an innovative biotechnology startup based in Watertown, MA, committed to developing groundbreaking therapies for diseases that current approaches cannot address. With our pioneering circular RNA technology, developed at MIT, we are at the forefront of advancing the next generation of RNA therapeutics. Our state-of-the-art expression and delivery platform positions us to tackle complex diseases, including B cell-driven autoimmune disorders, B cell malignancies, sickle cell disease, and beyond.

We are looking for a talented and driven Scientist to join our RNA Production Research Optimization (P.R.O.) team within the Platform Research department. This is a unique opportunity to contribute to the development of next-gen RNA-based therapeutics while expanding your expertise in a fast-paced, cutting-edge field. As a key member of the team, you will play a critical role in optimizing our RNA production processes, focusing on RNA engineering, purification, and assay development, to ensure the highest quality drug substances.

The ideal candidate will have in-depth experience in RNA engineering and a passion for advancing RNA therapeutics. You will work alongside experts in the field, contributing to the optimization of RNA processes that will impact the future of biotechnology. At Orna, we foster an environment where innovation thrives, growth is encouraged, and every team member is valued.

Responsibilities

• The candidate will be responsible for the development of in-vitro transcription (IVT) conditions and purification processes for RNA-based therapeutics to support various programs.
• Optimize reactions, starting materials, and process conditions.
• Contribute to downstream process development for purification of mRNA/circRNA.
• Develop mRNA/circRNA analytics for purity determination and impurity profiling.
• Complete detailed and timely experiment documentation with Benchling.
• Ability to supervise and mentor junior team members.
• Cross-train team members in mRNA/circRNA synthesis and purification.
  
  

Qualifications

• PhD in Biochemistry or Chemistry, with 0-2 years of relevant experience in RNA-related fields, or an MS with experience (6 years) of in vitro transcription and purification of mRNA/circRNA using chromatography and filtration techniques.
• Strong knowledge of nucleic acid or oligonucleotide chemistry and standard analytical techniques.
• Proficiency in analytical methods such as CE, HPLC, and LC-MS.
• Hands-on experience with AKTA purification systems and solid knowledge of Unicorn software.
• A strong publication or patent record is a plus.
• Experience in RNA design and engineering is highly desirable.
• Familiarity with ribozyme, particularly in catalytic efficiency and turnover, is a plus.
• Experience with automation and/or programming is a plus.
• The applicant must have excellent communication and collaboration skills.
• The applicant must be detail-oriented and is able to thrive in a fast-paced startup culture.
  
  

Why Orna? At Orna Therapeutics, we’re more than just a workplace—we’re a community. We believe in fostering an environment where individuals can grow, thrive, and make a lasting impact on the future of healthcare. Join us as we revolutionize RNA therapeutics and make a difference in the lives of patients around the world.

Equal Employment Opportunity Statement

Individuals seeking employment at Orna Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.