Scientist

Job Title: Scientist - II

Duration: 08 Months

Location: Boston, MA 02115

Shift Hours: M-F 8:30 AM To 5:00 PM

Qualification:

• A minimum of a B.S./ in a relevant field (e.g. protein sciences, chemical or bioengineering, biochemistry or similar) with additional training being desirable.

Must haves:

• Large molecules experience(Antibodies)

• LC-MS

Day to day:

• Lot of lab work

• Characterization

• Mass spec analysis

• Run any other biophysical assays

• Generate data and write reports

• ELN knowledge is desirable

Software Required:

MetaboAnalyst, Skyline, MaxQuant, Proteome Discoverer, EncyclopeDIA

Experience:

• BS with 6 years of experience/MS with 4 years./PHD with 1-3years.

• Industry experience is preferred.

Required experience and skills:

• Experience with mass spectrometry and other biophysical assays workflows and their inherent data management.

• Knowledge and hands on experience in LC-MS based sample preparation for proteins

• Strong problem solving and communication skills.

• Ability to multitask, time management, and prioritize activities.

Preferred experience and skills:

• Experience with operating high resolution MS instruments such as Agilent Q-TOF, Thermo Orbitraps (e.g. QE , QE-HF, Exploris 480) and liquid handling platforms such as Vanquish, Acquity UPLC.

• Experience analyzing data with BioPharma finder, BioConfirm and other MS software is a plus

• Experience with EMPOWER is a plus

• ELN knowledge is desirable

Note:

• 100% onsite role.

• 8 months assignment.

Responsibilities:

Contractor – Protein Analytics

Client is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where client has codified its legacy for over a century. Client’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Early Biologics Characterization – Boston of Client’s Research Laboratories (MRL) is seeking a contractor to execute on existing protein analytics workflows. Specifically, to perform intact MS, peptide mapping and other biophysical assays such as SEC, HIC, CE-SDS, DSF, DLS, Buffer Exchange.

In this role you will build and then use a combination of skills to help with the biologics characterization workflow. Additional laboratory automation skills are desired but not required. This role will require an eagerness to learn and an ability to work with different teams and different equipment to operate a robust characterization platform. Your efforts will be a complement and core resource to existing capabilities and will serve to expand the team’s ability to interrogate biologics diversity to identify optimal leads. You will have the opportunity to apply your enthusiasm and technical skills as a member of Discovery Biologics - Boston to support and help drive multidisciplinary biotherapeutic discovery programs.

Responsibilities

1. Operate and maintain existing mass spectrometry platforms and implement new workflows for protein characterization

2. Perform LC-MS data analysis using various software and bioinformatic tools to elucidate the quality attributes of therapeutics proteins and other novel modalities.

3. Troubleshoot automation methods and devices to maintain optimal high throughput protein analyses

4. Generate frequent characterization summary reports.

5. Follow and improve Standard Operating Procedures for biologics characterization workflows.