Protein Purification Scientist

PROTEIN PURIFICATION SCIENTIST

POSITION SUMMARY

The Process Science Department is a group of scientists and subject-matter experts who conduct process and analytical development experiments in support of drug substance and drug product development. This position is primarily a lab-based role which requires hands-on execution of downstream development, optimization and characterization experiments using small-scale chromatography models, along with analysis and interpretation of experimental data for transfer into cGMP commercial manufacturing of drug substance.

PRIMARY RESPONSIBILITIES

• Oversees and performs lab activities related to the development, optimization, characterization and scale-up of downstream protein purification processes
• Designs, plans, and executes experiments that support process development activities and project goals using semi-preparative chromatography, membrane technology and low-pressure chromatography (ion exchange, affinity, size exclusion).
• Provides downstream technical support for cGMP manufacturing operations by contributing insights to solve difficult technical issues and works to build alignment around complex situations.
• Effectively communicates and collaborates with scientists across the organization
• Maintains high-quality and organized records and documentation
• Maintains a safe work environment in accordance with policies, procedures, and regulations
• Resolves “stuck” issues by ensuring timely issue escalation to Leadership and cross-functional teams: Applies learning from these events and leads the creation of new/updated systems, processes, programs to prevent similar situations in the future.
• Through self-education and external networking/participation in industry and professional organizations keeps abreast of current industry trends, compliance requirements, and best-of-class technologies relating to area of responsibility. Actively applies learned best practices, knowledge, and benchmarking to PTx projects and solutions.
• Pursues participation or leads project teams outside normal course of work (i.e. “collateral duties”) as they become available to support personal growth, connection, and business needs.
• Adheres to all applicable regulations and requirements including compliance with internal SOPs, GMP, Health and Safety, WISHA/OSHA, regulatory compliance, company policies, and employment-related laws and statutes.
• Successfully completes all mandatory Quality and Compliance training within required timeframes.
• This job description is not intended to be all-inclusive. Partners may be required to perform other related duties as required to meet the ongoing needs of the organization.

KNOWLEDGE, SKILLS, ABILITIES

Required:

• Experience with Protein Purification
• Experience with Preparative HPLC
• Detail-oriented with the ability to independently perform laboratory experiments following a standard operating procedure
• Team player who can communicate and collaborate with cross-department collaborators
• Strong critical thinking, analytical, and problem-solving skills with the proven ability to formulate solutions to propel the organization forward.
• Resourceful with proven ability to lead, manage, and leverage an extensive internal network of stakeholders, team members, and external resources to plan and resolve issues. Strong, collaborative relationship management and interpersonal skills required to quickly gain confidence of stakeholders and team members.
• Possesses strong organizational and prioritization skills to maintain a high level of productivity and priority-setting in order to complete assignments on-time and on-budget.
• Excellent soft skills including a bias towards action, the ability and willingness to give and receive constructive feedback, is comfortable working within a diverse team and across multiple functions, exhibits a consistently constructive attitude, and is adaptable and at ease with handling unexpected changes and challenges.
• Solid English language communication skills, both oral and written, are required for this highly collaborative role. Willingness and ability to clearly express opinions and ask questions.  Comfortable actively participating in cross-functional meetings.
• Proficiency with MS Office products, especially Word and Excel essential; ability and willingness to quickly adopt other job-specific applications will be necessary.

Preferred:

• Experience with semi-preparative chromatography of a protein drug product
• Experience with HPLCs using Empower software control

EXPERIENCE & EDUCATION

Required:

• BS in Engineering, Chemistry, Biochemistry, or Pharmacy with 8 years of relevant industry experience; MS with 6 years; or PhD with 2 years.

PTx is committed to the principles of competitive and pay equity for all of our Partners. The current pay range for this position is $124,000 - 158,000: Offers are made within the base pay range applicable at the time. Your salary will vary depending on several factors including your qualifications and experience.

 In addition to medical, dental, vision, FSA/DCA, HRA, disability, and life insurance coverage, all full-time, regular Partners enjoy a casual, and Hybrid or Remote workplace program for many roles.  We offer a terrific compensation/benefits/perks package which includes pre-IPO options, annual cash bonuses, 401k matching, free parking or Seattle-area ORCA pass, tuition assistance, plus rewards for achievement and contribution. To support a healthy work-life balance we also provide a gym subsidy, wellness participation programs, and a generous vacation, sick, and holiday paid time off program in addition to a paid shutdown between the Christmas and New Year’s holidays.  

Partner Therapeutics is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, sex, age, national origin, veteran status, marital status, sexual orientation, gender identity, disability or any other category prohibited by local, state, or federal law. This policy applies to all aspects of employment, including recruitment, placement, promotion, transfer, demotion, compensation, benefits, social and recreational activities, and termination.  

Salary : $124,000 - $158,000