What are the responsibilities and job description for the Principal Scientist position at Pfizer?
Why Patients Need You
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Pfizer's purpose is to deliver breakthroughs that change patients' lives. Pfizer Vaccines Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into vaccines that matter most. You will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class vaccines to patients around the world.
What You Will Achieve
The primary purpose of Principal Scientist - Bacterial Immunoassays (PhD only) job is to provide expertise and support in assay development and immunology for early-stage bacterial vaccine programs. The incumbent will apply skills in immunology and host-pathogen interactions to design assays and experiments to aid the selection of vaccine candidates and generate preclinical data to validate and support proof of concept for novel vaccine candidates and formulations / platforms (e.g. subunit, polysaccharide conjugate, mRNA vaccines, novel adjuvants). Accordingly, the candidate should have experience with associated cell-based and immunological in vitro assays that measure the host response to the infecting pathogen. Experience in ex vivo assays to monitor and evaluate infection and immune responses in animal models is preferred. The incumbent may also collaborate with microbiologists to answer program critical questions about host-pathogen interactions. A strong focus on hands-on experimental work as individual contributor at the lab bench is expected. In addition to contributing individually, the scientist may supervise the activities of junior colleagues (formally or informally) and lead research projects.
The successful candidate will have a unique opportunity to work with a multidisciplinary team on a wide range of vaccine immunology research projects. Excellent communication skills and the ability to work in a multifunctional matrix environment are essential for the success of this candidate. This is an exciting opportunity for candidates with strong critical thinking skills and who want to work in a robust collaborative environment. The candidate will be expected to conduct experiments in the wet lab, manage laboratory and data analysis responsibilities to achieve team goals.
How You Will Achieve It
- Use knowledge of immunology to develop and execute in vitro assays to measure immune responses to immunization and understand vaccine mechanism of protection (e.g. total antibody binding, functional assays, T-cell assays).
- Develop ex vivo assays to support animal model development (e.g. assays to measure biomarkers of infection).
- Provide expertise and hands-on support in immunology and host-pathogen interactions for bacterial vaccine programs.
- Plan and execute complex experiments to further project goals. Research, plan and conduct experiments to evaluate immune responses to vaccination and mechanism of protection.
- Lead collaborations with cross-functional groups e.g. in vivo and clinical assay teams.
- Contribute original ideas and participate in project planning for individual and team goals.
- Independently design, develop and characterize serological assays.
- Interpret and summarize experimental data. Research and design experiments to resolve technical problems. Present original data at internal and external scientific meetings.
- Stay current in research tools and emerging approaches to evaluate immune responses to vaccination and host-pathogen interactions by keeping up with relevant literature and attending scientific meetings.
- Maintain laboratory notebook in a detailed and descriptive manner.
- Satisfactorily complete all cGMP / GLP and safety training in conformance with departmental requirements.
- Electronic documentation of lab work in a detailed fashion, summarizing and reporting data in an organized fashion.
- Prepare results for presentation, inclusion in technical reports, and for publication in peer-reviewed scientific journals.
- The incumbent has training on required Policies, Practices, and Procedures needed to support their work. Other technical training on job-specific tasks may be required.
Must have
Nice to have
To apply, please submit a resume accompanied by a cover letter.
Other Job Details
The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share-based long-term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver / parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.
Relocation assistance may be available based on business needs and / or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Salary : $99,900 - $166,500
