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Research Associate, Protein Sciences

Pioneering Medicines
Cambridge, MA Full Time
POSTED ON 2/6/2025
AVAILABLE BEFORE 3/7/2025
What if…you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform health care and sustainability?

Prologue Medicines is dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs. As part of our dynamic and collaborative team, you will have the opportunity to impact human health on a global scale.

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies’ Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com

Position Overview

Prologue Medicines is seeking a highly motivated and skilled Research Associate to join our dynamic Protein Sciences team. The successful candidate will contribute to platform and project advancement through interfacing with matrix teams and managing deliverables related to the protein production workflows. This full-time, on-site laboratory position offers an exciting opportunity to contribute to our computationally powered discovery initiatives in a fast-paced, entrepreneurial environment.

Key Responsibilities

  • Work collaboratively as part of the Protein Sciences team to generate protein constructs for discovery, in-vitro and in-vivo studies.
  • Maintain and optimize mammalian expression cell lines (HEK and CHO) for protein production.
  • Routinely perform small-scale and large-scale transient transfections to generate recombinant proteins.
  • Support the integration and optimization of custom automation technologies to support current and advanced production processes.
  • Data and statistical analysis using various software's like GraphPad Prism.
  • Maintain precise experimental records in an electronic laboratory notebook, ensuring data integrity and compliance with company policies.
  • Effectively communicate experimental findings in oral, written, and visual formats.
  • Work independently and collaboratively in a multidisciplinary team environment.

Required Qualifications

  • A bachelor's or master's degree in biochemistry, molecular biology, biotechnology, biological engineering, chemical engineering, or a related field and 0-2 years of industry experience
  • Experience with cell culture techniques, including growth, maintenance, and transformation, across a variety of cell lines.
  • Experience in cloning techniques and plasmid design/preparation.
  • Excellent problem-solving skills, with the ability to troubleshoot technical issues and implement effective solutions.
  • Outstanding organizational skills, attention to detail, and the ability to manage multiple projects simultaneously in a fast-paced environment.
  • Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams

Preferred Qualifications

  • Experience in biotechnology or pharmaceutical companies, with a preference for experience in recombinant protein or biologics production companies.
  • Experience with high-throughput protein expression and purification using automation is a plus.
  • Familiarity with molecular biology software applications like Geneious, SnapGene is a plus.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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