Senior Scientist, Discovery / In Vitro Pharmacology

Company Overview: Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of SynteinsTM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular scientists who are passionate about driving therapeutic modality innovation in biotechnology.

Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary: We are looking for a highly motivated, experienced cell biologist and assay development/screening scientist to join our growing team. In this role, the successful candidate will be responsible for developing and executing novel cell-based screening assays to drive the Abiologics SynteinTM discovery platform. This is a hands-on, lab-based role and will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company build-out. Occasionally, the incumbent may contribute to in vivo and ex-vivo pharmacology activities to progress the projects and the platform.

Key Responsibilities

• Design, develop and execute cell-based screening assays to assess SynteinTM activity, target engagement and mechanism of action to drive discovery programs
• Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas
• Collaborate within the Discovery and Biology teams on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
• Collaborate cross-functionally to enable novel methods, assays and screening workflows
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings
  
  

Qualifications

• PhD in molecular or cell biology or related discipline with minimum 3 years relevant experience in industry required
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, and reporter cell lines
• Proficient in industry-standard cell-based assay and bioanalytical techniques including TR-FRET, ELISA, flow cytometry, and reporter gene; experience with cellular/high content imaging and image analysis a plus
• Experienced with primary cell culture and characterization, including tissue dissociation and cell isolation of various immune cell types
• Demonstrated ability to independently design, develop and optimize diverse cell-based assays and interpret complex results
• In vivo pharmacology expertise highly desired
• Disease biology expertise in at least 2 of the following: immunology, or oncology, metabolism and neuroscience
• Proficiency in laboratory automation and semi-automated screening workflows a plus
• Industry level experience with best practices related to data records creation and maintenance and workflows integrity
• Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality
  
  

More About Flagship Pioneering

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.