What are the responsibilities and job description for the Scientist I/II, Analytical Development position at Prime Medicine, Inc.?
Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.
Position Overview:
We are currently seeking a talented and motivated Scientist I or II with expertise in HPLC and mass spectrometry to join the analytical development team in Prime’s Technical Development and Operations group. The candidate will play a key role in the application and development of a variety of HPLC, mass spectrometry (MS) and biophysical assays for the characterization of Prime editing components, drug substances and drug products across Prime’s portfolio, including long oligonucleotides (guide RNAs), conjugates, lipid nanoparticles (LNP), proteins, etc.
This is a hands-on role that provides an exciting opportunity to gain direct experience with all aspects of analytical development. The ideal candidate will excel as a member of a cross-functional team that works closely with the process development, formulation, chemistry, manufacturing, pharmacology, biology, and quality teams to advance the Prime Editing therapeutic product pipeline. The ideal candidate is an energetic learner, highly dependable, detail-oriented, multitasking bench scientist with demonstrated abilities for generating high-quality data in a multidisciplinary team setting.
Key Responsibilities:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.
Position Overview:
We are currently seeking a talented and motivated Scientist I or II with expertise in HPLC and mass spectrometry to join the analytical development team in Prime’s Technical Development and Operations group. The candidate will play a key role in the application and development of a variety of HPLC, mass spectrometry (MS) and biophysical assays for the characterization of Prime editing components, drug substances and drug products across Prime’s portfolio, including long oligonucleotides (guide RNAs), conjugates, lipid nanoparticles (LNP), proteins, etc.
This is a hands-on role that provides an exciting opportunity to gain direct experience with all aspects of analytical development. The ideal candidate will excel as a member of a cross-functional team that works closely with the process development, formulation, chemistry, manufacturing, pharmacology, biology, and quality teams to advance the Prime Editing therapeutic product pipeline. The ideal candidate is an energetic learner, highly dependable, detail-oriented, multitasking bench scientist with demonstrated abilities for generating high-quality data in a multidisciplinary team setting.
Key Responsibilities:
- Assist with all aspects of analytical development, including new assay development, qualification and validation, and supporting routine sample analysis and stability testing.
- Contribute to new analytical method development to augment Prime’s analytical capabilities, including release, characterization, stability, and activity/potency assays.
- Conduct sample analysis for the characterization and release testing of Prime editing components, following experimental design, protocols, and standard operating procedures (SOP).
- Contribute to analytical sections in support of regulatory submissions.
- Assist in method transfer to CTLs (contract testing labs) and CDMOs (contract development and manufacturing organizations).
- Maintain electronic lab notebook following data integrity principles and practices.
- Effectively communicate results to multi-disciplinary teams in oral and written formats.
- Willingness to learn new skills and processes.
- BS/MS/PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline.
- At least 5 years experience in the biotechnology or pharmaceutical industry for BS candidates, 3-6 years for MS and 0-3 years for PhD candidates.
- Experience with HPLC and/or LC-MS based analytical method development, qualification and/or validation.
- Experience with macromolecule analysis (proteins, antibodies, oligonucleotides, mRNA, etc.) is a plus.
- Capable of continuous improvement, learning new things, open-minded, curious, highly organized and detail-oriented.
- Strong collaborator with cross-functional teams.
- Ability to adapt quickly in a fast-paced environment with changing priorities.
- Highly self-motivated, driven, can-do, make it happen attitude.
