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Senior/Principal Scientist, Protein Science

Proclinical
Indianapolis, IN Full Time
POSTED ON 2/21/2025
AVAILABLE BEFORE 5/20/2025

Senior / Principal Scientist, Protein Science - Permanent - Indianapolis, IN

Proclinical is seeking a Senior / Principal Protein Scientist to join a dynamic discovery group.

Primary Responsibilities :

The successful candidate will be required to focus on the design, production, and characterization of chemical leads and drug candidates. This role is pivotal in advancing a drug discovery portfolio, particularly in the area of metabolic diseases.

Skills & Requirements :

  • Advanced degree in Biochemistry, Biology, Chemistry, or related field.
  • Expertise in peptide and protein work, purification, and analytical techniques.
  • Proficiency with electronic inventory systems and lab notebooks.
  • Strong command of Microsoft Suite.
  • Self-starter with excellent problem-solving skills.
  • Strong organizational and project management abilities.
  • Effective communication and interpersonal skills.
  • Experience in peptide and protein modification, biophysical techniques, and drug formulation is preferred.
  • Knowledge of drug discovery and development processes is advantageous.

T he Senior / Principal Scientist's responsibilities will be :

  • Design and recommend peptides and proteins with therapeutic potential.
  • Conduct or coordinate protein expression and purification.
  • Perform chemical conjugation or enzymatic ligation of peptides and proteins.
  • Purify drug candidates using techniques like RP-HPLC, IEC, or SEC.
  • Formulate drug candidates for downstream screening and analysis.
  • Characterize synthesized compounds using LCMS, SEC, and SDS-page.
  • Conduct biophysical characterization to ensure compounds meet purity and identity standards.
  • Analyze data and present findings to multidisciplinary teams.
  • Maintain detailed laboratory records and documentation.
  • Collaborate with chemists, biologists, and pharmacologists to advance drug candidates.
  • Communicate progress and challenges to stakeholders.
  • Ensure compliance with regulatory requirements and safety protocols.
  • Participate in laboratory inspections and audits.
  • Compensation :

  • 115,000 to $120,000 per annum.
  • Salary : $115,000 - $120,000

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