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Senior Chemist

Quadratic 3D, Inc.
Charlestown, MA Full Time
POSTED ON 3/26/2025
AVAILABLE BEFORE 5/26/2025

Description

We are seeking a passionate PhD-level synthetic chemist to drive the discovery of small molecules for next-generation 3D printing resins. Similar to a drug discovery role, this position involves rapid exploration of chemical space through organic synthesis to develop structure-property relationships. However, our feedback loops take only days rather than months or years, and the structure-property relationships involve diverse photochemistry. This role is particularly appealing to synthetic chemists with a passion for physical organic chemistry. Our process uses a small amount of each lead candidate, so synthetic creativity is not limited by the scalability concerns that usually narrow the available chemical space in materials applications.

Responsibilities:

  • Design, refine, and troubleshoot small molecule synthetic routes, with a focus on divergent or modular approaches to rapidly generate lead candidates.
  • Characterize lead candidates via UPLC, NMR, UV/Vis and IR spectroscopy, and mass spectrometry.
  • Contribute to the development of high-throughput analytical capabilities, small molecule databases, and virtual libraries.
  • Work closely with analytical chemists and chemical engineers to establish structure-property relationships in formulations containing lead candidates.

Minimum Qualifications:

  • PhD in Organic Chemistry or BS in Chemistry and 5 years of experience in a small molecule discovery role.
  • Candidates should have strong expertise in both synthetic and physical organic chemistry, demonstrated through publications and other activities.
  • Significant experience designing and executing multi-step synthetic routes.
  • Extensive experience with modern computing and data analysis tools relevant to synthetic chemistry.
  • Excellent communication, organizational, and time management skills.   
  • Demonstrated ability to independently drive an idea from conception to project completion.
  • Evidence of strong collaboration and teamwork talents/skills.
  • Strong publication record, both as lead author and as contributor to other projects.

Preferred Qualifications:

  • Expertise in photochemistry and/or radical chemistry.
  • Experience with synthesis of heterocyclic and/or extended aromatic systems, especially those relevant to organic (opto)electronics. Experience with cheminformatics and/or computational chemistry tools (e.g. DFT) relevant to the production of structure-property relationships.

Additional Information:

  • Travel: Occasional travel may be required from time to time
  • Location: Boston, Massachusetts

We value diversity in our company and are an Equal Opportunity Employer. 

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