What are the responsibilities and job description for the Scientist II, Biology (Proteomics) position at Radionetics Oncology?
About Radionetics
Radionetics Oncology, Inc. is a clinical stage company focused on the discovery and development of novel radiopharmaceuticals for the treatment of a wide range of oncology indications and is poised to capitalize on the increasing demand for novel radiotherapeutics. Radionetics Oncology is supported by Frazier Life Sciences, 5AM Ventures, DCVC Bio, Crinetics Pharmaceuticals, and GordonMD Global Investments and has entered into a strategic agreement with Eli Lilly. Radionetics is advancing a pipeline of first-in-class small molecule radioligands targeting G protein coupled receptors for the treatment of a broad range of cancers, including breast cancer, lung cancer, and other indications of high unmet need. For more information, visit https://radionetics.com.
Position Summary
The Scientist, Biology (Sci) is a dynamic and hands-on member of the proteomic team efforts that support the target identification and validation for the development of radiopharmaceuticals for solid tumors. The Sci is a technical expert in proteomic target identification using mass spectrometry including sample preparation, data collection and data analysis. The Sci is well versed in mass spectrometry instrumentation and is responsible for required maintenance of mass spectrometer and related lab instrumentation. The Sci is an integral member of a team of highly skilled scientists with diverse skill sets. The Sci is a key member of the proteomics team by presenting results and participating in cross-functional teams to develop innovative solutions that drive forward multiple discovery programs in parallel.
Essential Job Functions And Duties
The position is based on-site in San Diego, CA.
Compensation & Benefits
Radionetics has a competitive total compensation package that includes bonus opportunity; equity; medical, dental, vision, life, short-term, and long-term disability insurance; 401(k) retirement plan; 4 weeks of paid time off (PTO) annually; and generous paid holidays.
Pay Range: $124,800 - $147,200
Radionetics evaluates a variety of factors in determining individual pay decisions, which may include relevant education, experience, and skills; internal equity; complexity and responsibility of the role; and market demand relative to the position. Geographic location may also be a consideration in evaluating salary when candidates work in states outside of California.
Important notices
Radionetics Oncology, Inc. is committed to a policy of equal opportunity in which all qualified applicants receive equal consideration for employment without regard to race, color, national origin, ancestry, religion, sex, pregnancy, marital status, sexual orientation, gender, gender identity and expression, age, physical and medical disability, medical condition, genetic information, military or veteran status, or any other federal, state or local protected class.
The job description specifics provided above are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities and requirements. Radionetics retains the right to add or change duties, education, experience, skills or any other requirements of the position at any time.
Radionetics does not accept unsolicited referrals from employment agencies for position vacancies unless written authorization is provided from the Human Resources department before any candidates are referred for specific identified positions. In the absence of such written authorization, any actions taken by the employment business/agency shall be deemed to have been performed without consent or contractual agreement, and Radionetics shall not be liable for any fees arising from such actions or referrals for position vacancies at Radionetics.
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Radionetics Oncology, Inc. is a clinical stage company focused on the discovery and development of novel radiopharmaceuticals for the treatment of a wide range of oncology indications and is poised to capitalize on the increasing demand for novel radiotherapeutics. Radionetics Oncology is supported by Frazier Life Sciences, 5AM Ventures, DCVC Bio, Crinetics Pharmaceuticals, and GordonMD Global Investments and has entered into a strategic agreement with Eli Lilly. Radionetics is advancing a pipeline of first-in-class small molecule radioligands targeting G protein coupled receptors for the treatment of a broad range of cancers, including breast cancer, lung cancer, and other indications of high unmet need. For more information, visit https://radionetics.com.
Position Summary
The Scientist, Biology (Sci) is a dynamic and hands-on member of the proteomic team efforts that support the target identification and validation for the development of radiopharmaceuticals for solid tumors. The Sci is a technical expert in proteomic target identification using mass spectrometry including sample preparation, data collection and data analysis. The Sci is well versed in mass spectrometry instrumentation and is responsible for required maintenance of mass spectrometer and related lab instrumentation. The Sci is an integral member of a team of highly skilled scientists with diverse skill sets. The Sci is a key member of the proteomics team by presenting results and participating in cross-functional teams to develop innovative solutions that drive forward multiple discovery programs in parallel.
Essential Job Functions And Duties
- Design and perform proteomics experiments to analyze protein expression, modification, and interactions using techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), DDA, DIA, and targeted proteomics
- Develop and optimize experimental protocols for membrane protein extraction, purification, and quantification from a variety of biological samples (e.g., fresh frozen and FFPE tissues, cells, serum)
- Analyze complex proteomics data, including protein identification, quantification, and post-translational modifications, using bioinformatics tools and software (e.g., Spectronaut, MS Fragger, DIA-NN, Skyline, etc)
- Perform routine maintenance, cleaning, and calibration of LC-MS system (Evosep-TimsTOF Ultra) and other proteomics-related equipment to ensure optimal performance and longevity. Diagnose and resolve technical issues with instruments, including hardware, software, and method-related problems
- Conduct routine QC checks to ensure instrument performance meets established standards. Analyze QC data and implement corrective actions as needed. Maintain detailed records of instrument maintenance, calibration, troubleshooting, and QC activities. Prepare reports and documentation as required
- Perform other responsibilities as required by business needs
- Ph.D. in Proteomics, Biochemistry, Molecular Biology, or a related field, or a Master’s degree with relevant experience
- Minimum 3 years of hands-on experience operating mass spectrometry-based proteomics instrumentation (LC-MS/MS), preferably the Bruker timsTOF and timsTOF Ultra systems
- Experience with laboratory techniques such as membrane protein purification, immunoprecipitation, and Western blotting
- Experience in proteomics and molecular biology approaches to study membrane proteins by mass spectrometry
- A proven track record optimizing sample preparation and mass spectrometry methods for functional proteomic studies
- Strong knowledge of protein biology, including protein modifications (e.g. glycosylation, phosphorylation, ubiquitination), protein-protein interactions, and protein structure-function relationships
- Experience operating HPLC separation (standalone HPLC) is a plus
- Familiarity with common software for data analysis (e.g. DIA_NN, Spectronaut, MaxQuant, MSFragger, Skyline, R, Python)
- Excellent problem-solving, organizational, and analytical skills
- Strong written and verbal communication skills, with the ability to effectively collaborate across teams
- Ability to work independently and manage projects simultaneously
The position is based on-site in San Diego, CA.
Compensation & Benefits
Radionetics has a competitive total compensation package that includes bonus opportunity; equity; medical, dental, vision, life, short-term, and long-term disability insurance; 401(k) retirement plan; 4 weeks of paid time off (PTO) annually; and generous paid holidays.
Pay Range: $124,800 - $147,200
Radionetics evaluates a variety of factors in determining individual pay decisions, which may include relevant education, experience, and skills; internal equity; complexity and responsibility of the role; and market demand relative to the position. Geographic location may also be a consideration in evaluating salary when candidates work in states outside of California.
Important notices
Radionetics Oncology, Inc. is committed to a policy of equal opportunity in which all qualified applicants receive equal consideration for employment without regard to race, color, national origin, ancestry, religion, sex, pregnancy, marital status, sexual orientation, gender, gender identity and expression, age, physical and medical disability, medical condition, genetic information, military or veteran status, or any other federal, state or local protected class.
The job description specifics provided above are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities and requirements. Radionetics retains the right to add or change duties, education, experience, skills or any other requirements of the position at any time.
Radionetics does not accept unsolicited referrals from employment agencies for position vacancies unless written authorization is provided from the Human Resources department before any candidates are referred for specific identified positions. In the absence of such written authorization, any actions taken by the employment business/agency shall be deemed to have been performed without consent or contractual agreement, and Radionetics shall not be liable for any fees arising from such actions or referrals for position vacancies at Radionetics.
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Salary : $124,800 - $147,200