Senior Manager/Associate Director, Analytical Chemistry

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder.

The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!

Your Impact

Reporting to the SVP of CMC and Product Development, you will be responsible for 1) developing and implementing analytical methods at external CDMOs in both the Drug Substance and Drug Product realms across both early- and late-stage small molecule programs and 2) contributing to CMC program management. These activities include optimizing existing analytical methods, overseeing analytical validation, and collaboration with internal and external colleagues on registration and validation manufacturing campaigns and document management.

Your Day-to-day

• Develop and implement phase-appropriate methodologies and strategies for analytical development on early- and late-phase clinical programs
• Interpret and summarize analytical data to support drug substance and drug product development to lead discussions at internal meetings, facilitate technology transfers, and contribute to regulatory filings
• Designing and interpreting process development, forced degradation studies, comparability assessments, stability studies, process characterization, etc.
• Collaborate closely with drug substance, drug product, quality, bioanalytical, and regulatory colleagues to achieve company’s objectives
• Perform risk assessment to identify potential analytical shortcoming and developing mitigation strategies
• Manage activities of analytical chemistry team members at external CDMOs for method development, qualification, and validation activities
• Manage analytical budget and timelines for internal and external activities
• Contributing to cross-functional CMC program management via document management and other communication tools
  
  

Must-Haves

• Bachelor’s degree or Masters Degree or Ph.D. in analytical chemistry or related field (title commensurate to education and experience)
• 8 years of experience with external management of analytical activities at CDMOs (title commensurate to education and experience)
• Prior analytical laboratory and management experience in leading a team of scientists at a clinical stage biotech environment
• Knowledge of GMP/GCP SOPs and ICH guidance for small molecules
• Prior experience with analytical assays to support small-molecule development, method troubleshooting, and optimizing analytical methods
• Ability to drive operational excellence via continuous process improvements
• Ability to work in a fast-changing and deadline-driven environment
• Hybrid position with 1 day per week in Boston office
• Ability to travel to CDMO collaborators (up to 10%)
  
  

What Makes Rapport Special

• Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel passion from the start.
• We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
• Your perspective matters. Stick your neck out, share your ideas – we work as a team.
• We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.
• Leadership that CARES – about you, your growth development.
• We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.
• Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
• You get to be YOU! Show up as you are and make every day count.
  
  

Your Compensation

We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for this role to be $155,000 to $180,000 (Senior Manager level) or $190,000 to $220,000 (Associate Director level). Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.

Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

CCPA disclosure notice can be found here.