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Sr. Scientist, Molecular Neurobiology

Rapport Therapeutics
San Diego, CA Full Time
POSTED ON 2/27/2025
AVAILABLE BEFORE 5/26/2025

When our people share why they joined Rapport and love it here, it comes down to three things : the science, the mission, and the team. At Rapport, we're driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we're doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder.

The strength of Rapport comes from our Rapptors - who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you're as excited about this opportunity as we are!

Your day-to-day :

As a Senior Scientist, Molecular Neurobiology, you will be at the forefront of our efforts to advance impactful drug discovery programs. Key responsibilities include :

  • Independently design, develop and execute biology experiments to drive preclinical target biology.
  • Lead the target identification efforts using platform, responsible for assay setup and development.
  • Lead biology projects, actively participate in and partner with multidisciplinary drug discovery teams. Proactively review discovery research literature to contribute the newest scientific findings, ideas, and methods / technologies to the team.
  • Identify and manage CROs for various research activities.
  • Interpret, summarize, and present research findings in internal and external scientific meetings / conferences.

Must-Haves :

  • Ph.D. in neuroscience, pharmacology, or cell biology, plus 3 years industry experience with high impact, peer reviewed publications and a proven track record of productivity and creativity.
  • Exceptional cell biology skills (including primary cell and cell line culture), and expertise in molecular neurobiology (Such as ion channel and GPCR) are required.
  • Experience in automation and high throughput screening assay development is required.
  • Experience in electrophysiology, Calcium FLIPR assay or high-content imaging is preferred.
  • Capability to work within a dynamic matrix environment, with strong contribution to project strategies and progression.
  • Excellent communication, presentation, and inter-personal skills; superb organizational and problem-solving skills.
  • Leadership in technology development and implementation, and familiarity with various routine laboratory assay methodologies : cell transfection; design and use of lentiviral vectors for gene delivery; cellular immunostaining.
  • What makes working here great :

  • Every role has meaning. We're determined to discover a better way for patients, and you'll feel the passion from the start.
  • We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
  • Your perspective matters. Stick your neck out, share your ideas - we work as a team.
  • We have FUN. We hire smart, dedicated, down-to-earth people that you'll enjoy spending time with.
  • Leadership that CARES - about you, your growth development.
  • We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston - we make the most of our time together.
  • Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
  • You get to be YOU! Show up as you are and make every day count.
  • The anticipated salary range for candidates who will work in San Diego CA is listed below. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, education, etc. Rapport Therapeutics, is a multi-state employer and this salary range may not reflect positions that work only in other states.

    California Salary Range

    130,000-$155,000 USD

    Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

    Note to Employment Agencies : Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

    CCPA disclosure notice can be found here.

    Salary : $130,000 - $155,000

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