What are the responsibilities and job description for the Process Development Radiochemist position at Ratio Therapeutics, Inc.?
Process Development Chemist
About Ratio Therapeutics
Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM™ and MACROPA™ platforms: TRILLIUM™ allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA™ simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These enabling platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.
About the Position
Ratio is seeking a Process Development Radiochemist to join our growing team of scientists. In this role, the successful candidate will be responsible for radiopharmaceutical manufacturing process development. The ideal candidate has a track-record of successful technology development, enjoys working in a collaborative and fast-paced environment, and will seek to maintain trustworthy relationships with interdisciplinary teams at partner organizations.
Key Responsibilities
· Lead the development of radiopharmaceutical production processes to support advancement of Ratio’s lead compounds. Occasional business travel may be required (approximately 5-10%) to facilitate technology transfer activities at CDMO sites.
· Lead technology transfer of radiopharmaceutical production processes to CDMO sites.
· Lead the drafting, review, and approval of protocols, methods, and relevant IND/IMPD sections.
· Lead the planning and execution of novel and state-of-the-art radiochemistry experiments to support the development of novel radiopharmaceuticals.
· Participate in the development, maintenance, and revision of radiation safety procedures.
Key Qualifications and Requirements
· University/college degree in Chemistry, Biochemistry, or similar. Experience in pharmaceutical manufacturing process development (at least 4 years of experience for PhD, 6 years for MSc, 8 years for BSc). Radiopharmaceutical manufacturing experience is required.
· Deep understanding of CGMP and ICH/FDA guidelines and interest in advancing knowledge in this area.
· Experience with project management (experience managing external CROs or CDMOs is an asset)
· Aptitude in technical writing
· Ability to work effectively in a team environment
· Attention to detail and a quality oriented mindset
· Familiarity and interest in working with radioactive materials. Experience working with radioactive materials is an asset.
· Must be able to lift up to 45 lbs. (handling of lead and tungsten vial/syringe shields for radioactive materials)
· Open-minded and self-motivating attitude
· Computer skills (Microsoft Office suite)
If you want to become part of an entrepreneurial team, if you are prepared to assume responsibilities and if your background and personal experience fits this profile, please send us your complete application (Cover letter detailing your interest in this position including your past relevant research and work experience, CV, and publication list if applicable).
