What are the responsibilities and job description for the Executive Director, Clinical Development position at Revolution Medicines?

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity :

We are seeking an experienced drug developer and effective leader to serve as Executive Director of Clinical Development in support of Revolution Medicines’ clinical-stage molecule(s) including RMC-9805 and / or RMC-6236. In this critical role, you will be responsible for developing the strategic plans and ensuring efficient operational execution of the molecule(s)’ clinical development program in one or more disease indications, from early-stage studies to regulatory submissions and potential commercialization. You will play a pivotal role in shaping the future of our pipeline and driving the development of transformative therapies for patients.

Key Responsibilities :

Provide critical insights / contributions and implement comprehensive / execute upon the clinical development plans for Revolution Medicines’ molecules, ensuring alignment with scientific, regulatory, and commercial objectives.
Lead, mentor, and manage a high-performing cross-functional team of clinical development professionals, fostering a culture of collaboration, innovation, and excellence.
Oversee all aspects of clinical trial design and execution, including site selection, patient recruitment, data management, and regulatory compliance.
Establish and maintain strong relationships with clinical investigators, regulatory agencies, and key stakeholders.
Gather, analyze and interpret clinical data, providing strategic insights to inform critical decisions and guide program development.
Manage clinical development timelines effectively, ensuring efficient resource allocation and achievement of milestones.
Stay abreast of the latest scientific advancements and regulatory trends in the field of clinical development.
Partner with cross-functional teams, including research, regulatory affairs, commercial, and finance, to ensure seamless program execution and achieve shared goals.
Manage multiple direct reports and be a manager of managers.

Required Skills, Experience and Education :

MD, PhD or similar biomedical graduate degree with 8 or more years’ experience in pharmaceutical / biotech industry.

Extensive experience working with the principles and techniques of data analysis, interpretation, and clinical relevance as related to the pharmaceutical / biotech industry.

Proven track record of successfully designing and conducting multiple clinical trials as part of a wider clinical development programs from early-stage to late-stage, direct experience with Phase 1 drug development.

Experience authoring and clinical development strategy(ies) and bringing forward for governance.

Extensive understanding of medical aspects of GCP (Good Clinical Practice), ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use), FDA, EMA, and other relevant guidelines and regulations.

Proven experience to steer an IMP during its clinical development plan through major and varied Health Authority interactions (e.g. FDA, EMA, others). Has led Health Authority interaction(s).

Strong orientation to teamwork. Excellent leadership, communication, and interpersonal skills, with the ability to inspire, motivate and mentor a diverse team.

Expertise in building and maintaining strong relationships with internal and external stakeholders.

Superb strategic thinking and analytical skills, with the ability to make data-driven decisions in a fast-paced environment. Able to recognize trade-off decisions and can determine priorities and goals.

Outstanding written and business presentation skills. Experience publishing results of a clinical trial in a peer-reviewed journal is required.

Proven ability to manage budgets and timelines effectively.

Passion for innovation and a commitment to developing therapies that make a meaningful difference in patients' lives.

Preferred Skills :

Experience in ongoing enhancements / development of core and sub-team processes, structures, systems, tools and other resources in the pharmaceutical / biotech industry.

Experience creating clinical development strategy(ies) that led to label-enabling outcomes and commercialization.

Experience submitting an NDA / BLA / MAA to global health authorities is a significant plus.

Has led regulatory and other internal partners / stakeholders in the completion and submission of regulatory documentation. Successfully provided clinical science information and input for regulatory development of label(s) and packaging language, etc.

Has led or overseen data generation to address unmet medical needs and identify new or extended Clinical Development studies for the assigned program or other programs.

Direct experience with Phase IV drug development.

Has proven abilities to present [a] compelling business case and facilitates effective and expeditious decision-making. Has demonstrated the ability to serve as a company spokesperson both internally and externally.

Has demonstrated collaborative behaviors on enterprise-level strategic initiatives with a variety of internal and external partners and stakeholders - including clinical investigators / clinicians, scientists and key opinion leaders (KOLs), as well as internal groups, including other groups in development, research, business development, commercial, legal, etc. - resulting in demonstrable outcomes (e.g. new study proposals or new disease indications).

Has demonstrated courage and conviction in past positions and responsibilities. Skilled in conflict resolution.

The base salary range for this full-time position is $256,000 to $320,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity / expression, national origin / ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes the protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact privacy@revmed.com .

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Salary : $256,000 - $320,000

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