Scientist II, Biology

About Rezo Therapeutics

Rezo is a different kind of biopharma company.  Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.  

Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs. 

Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements.  If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us! 

The Opportunity

As part of Rezo’s Biology Team, you will collaborate with an interdisciplinary group combining genetics, proteomics, structural biology, and AI to tackle challenging biological questions and develop transformative cancer therapies. Joining Rezo at this early stage provides a unique opportunity to contribute to our groundbreaking platform and drive therapeutic discovery.

We are seeking a Scientist II with expertise in CRISPR gene-editing technologies and strong experience in immunology and/or cancer biology to design and execute innovative cellular assays for target validation and active therapeutic programs in our pipeline.

• Implement advanced molecular and cellular techniques to study target functions in 2D/3D tumor models.
• Apply CRISPR gene-editing technologies to conduct genetic studies with technical excellence.
• Design, execute, and analyze key biological experimental strategies to define drug mechanism of action, develop novel disease models and biomarkers for target engagement and patient selection with a high level of independence and creativity.
• Manage and analyze experimental data, interpret results, and prepare necessary materials for internal and external meetings, regulatory filings, and publications.
• Communicate and collaborate across diverse interdisciplinary research teams.
• Manage multiple projects effectively in a dynamic, fast-paced environment.

• Education and Experience:
• PhD in cellular/molecular biology, cancer biology, or immunology with relevant postdoctoral or industry experience.
• Non-PhD candidates with substantial and demonstrated expertise in CRISPR technologies and cancer research are encouraged to apply.
• Expertise and Skills:
• Hands-on experience with in vitro 2D/3D tumor models.
• Proficiency in molecular biology techniques, including genetic manipulation of mammalian cells, immunoblotting, proliferation/apoptosis assays, and other phenotypic assays related to oncogenic pathways.
• Strong background in oncogene and/or immunology is highly desirable.
• Demonstrated ability to work independently while contributing to a collaborative team environment.
• Exceptional communication, organizational, and interpersonal skills.

Compensation at Rezo

The expected starting salary range for this position based in San Francisco, California is $115,000-$165,000. Actual starting salary will be determined based on multiple job-related factors including a candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance

Discretionary time off policy

Company holidays (including summer and winter shutdown)

401(k) retirement savings program

Commuter / Mass Transit Benefit Program

Healthcare Flexible Spending Account (FSA)

Dependent care Flexible Spending Account (FSA)

Parental leave

Competitive compensation

Flexible work schedule

EEOC

At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  This statement covers all facets of employment and is especially important when it comes to growing our team.  

If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!

SF Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.

Salary : $115,000 - $165,000