What are the responsibilities and job description for the Principal Applied Scientist position at Ripple?
The Translational Medicine department at Client informs clinical development of Client personalized therapeutics through establishment of biomarker strategies aimed to study biological pathways driving disease and by characterizing the mechanism of action of Client therapeutics.As a key member of the biomarker mass spectrometry laboratory, the ideal candidate will utilize mass spectrometry to explore Client biomarker hypotheses, assist in streamlining existing workflows, and help to drive innovation within the group through improved LC-MS / MS method development.Responsibilities : Utilize mass spectrometry to explore biomarker hypotheses.Streamline existing workflows.Drive innovation through improved LC-MS / MS method development.Minimum Requirements : PhD in Analytical Chemistry, Biochemistry, or Biotechnology and successful postdoctoral research training in a related field.Minimum of years of hands-on experience with liquid chromatography and tandem mass spectrometry (LC-MS / MS) approaches.Strong analytical background with fundamentals in assay development, system suitability, and method evaluation.Experience with discovery proteomics approaches (TMT, DIA-MS, SWATH, etc.) and corresponding data analysis tools.Knowledge of sample preparation techniques for analysis of biomarkers and other mediators from biological fluids (plasma, CSF, urine, stool, etc.).Proven ability to analyze and visualize complex datasets using tools like MSstats, Spotfire, R, or Skyline and experience with standard instrument software such as Analyst or Xcalibur.Excellent communication, presentation, and interpersonal skills.Able to work independently as well as in a team environment.Willing and eager to learn and train others on new technologies.#J-18808-Ljbffr
