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Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail.
Title : Global Head of Process Engineering – Synthetics
Location : Sisteron, Montpellier – France / Cambridge, US
About the job :
Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. Join our Synthetics CMC Development team in R&D as a Head of Process Engineering and you’ll contribute to our mission to serve patients, while enjoying lots of opportunities to broaden your experience and hone your skills.
Within R&D, our Synthetics CMC Development team is managing all aspects of synthetic / small molecule drug development, from candidate selection to product approval. This encompasses drug substance (DS), oral drug product (DP) and analytical development, DS / DP clinical manufacturing, and support of global regulatory filings from IND submission to NDA approval. Our mission is to serve patients through relentless innovation in synthetic drug development and by designing state of the art manufacturing processes. To this end, our development model is focused on speed to clinic for early-stage programs and delivering safe, robust, and eco-designed late-stage and commercial processes.
Main responsibilities :
- Reporting to the Global Head of Synthetics CMC Development, you will be a member of the Synthetics Leadership Team, responsible for devising the science, innovation, and CMC strategy for all synthetic / small molecule drug candidates
- You will lead a global organization (~50 FTEs in France / USA) responsible for applying cutting-edge process engineering principles across both drug substance (DS) & drug product (DP) design
- You will drive the development of innovative, efficient, environmentally friendly, cost-effective, and phase-appropriate DS / DP manufacturing processes for Sanofi’s small molecule R&D pipeline
- You will be responsible for supporting clinical / commercial process development, risk assessments, QbD (Quality by Design) control strategy, tech transfer, scale-up and process performance qualification / validation
- You will develop and deploy advanced technologies for automated experimentation, robotics, lab informatics, predictive modeling, crystallization, integration of process analytical technologies, kinetic / mechanistic analysis of synthetic transformations
- You will drive the application of artificial intelligence & machine learning tools for process simulation and optimization
- You will establish technology platforms for activities such as DS / DP continuous manufacturing, process safety / thermal hazards evaluation, unit operation modeling, development of digital twins, crystallization, solubility enhancement, rapid formulation development, and process characterization
About you :
Why choose us :
Pursue Progress . Discover Extraordinary .
Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing : a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.
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