Principal Scientist I, In Vivo Antibody Discovery

Job title: Principal Scientist I, In Vivo Antibody Discovery

Location: Cambridge, MA

About The Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

We are seeking a highly motivated and experienced Principal Scientist in the field of Antibody Bioinformatics and Molecular Biology to lead innovative research and development initiatives. The successful candidate will play a critical role in advancing our understanding of antibody therapeutics through bioinformatics approaches, focusing on the NGS data analysis, application of AI models to improve/generate target-specific antibodies, and apply molecular biology processes for antibody generation. This position offers a unique opportunity to work in a dynamic biotech environment focused on cutting-edge antibody technologies. The role may involve both computational analyses and laboratory-based work, requiring adaptability and a strong commitment to scientific excellence.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities -

• Data analysis: The scientist will utilize advanced bioinformatics tools and techniques to analyze large NGS datasets, including V-genes, and B-cell transcriptomic for antibody discovery and development. The ability to use antibody sequence data and associated properties to train predictive and generative ML-models will be considered as a plus.
• Data integration: Integrate diverse biological data for clone selection from early to late-stage antibody discovery. In-charge of maintaining data in the respective databases and accessibility during requirement.
• Molecular biology: The scientist is required to contribute in the development of new innovation in molecular biology of antibody cloning, expression, and NGS library.
• Mentorship: Provide guidance to junior scientists in data analysis and molecular biology.
• Collaboration: Work closely with the immunologists, protein engineers, and molecular biologists to translate bioinformatics findings into actionable insights for therapeutic development. Lead cross-functional teams to achieve project goals.
• Communication: Present research findings clearly and effectively to internal stakeholders and at scientific conferences. Prepare detailed reports and publications.
  
  

About You

Preferred qualifications -

• Education: Ph.D. in bioinformatics, molecular biology, immunology, or a related field.
• Experience: Minimum of 5-10 years of relevant experience in antibody research or bioinformatics within an academic or industrial setting.
• Technical Skills:
• Proficiency in programming languages such as Python or R for data analysis.
• Experience with bioinformatics tools for sequence analysis, structural modeling, and machine learning applications.
• Familiarity with antibody engineering techniques and therapeutic development processes.
• Soft Skills: Strong problem-solving abilities, excellent communication skills, and the capacity to work effectively in a multidisciplinary team.
  
  

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
  
  

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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