Scientist Cell Line Development

Job title: Scientist Cell Line Development

Location: Framingham, MA

About The Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

The Cell Science and Technology Department at Sanofi is seeking a highly motivated candidate to join a high-performing, collaborative team focused on optimizing our internal CHO cell line development expression system. Responsibilities will focus on improving process workflows, expression system components, and CLD methods used to generate recombinant CHO cell lines for production of protein biologics. This will include the design and generation of new CHO expression platforms for semi-targeted and targeted integration. The ideal candidate will possess a strong molecular background and expertise in cellular biology / cell line engineering. Work will directly support development projects in Sanofi’s pipeline and will include frequent cross-functional interactions with colleagues across Sanofi’s global CMC sites.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

• Design, execute and analyze research work packages to support development of new expression platform components to improve cell line productivity and product quality of mAbs and various multi-specific formats.
• Generation of vector constructs for expression of candidate biotherapeutic molecules
• Perform cell culture techniques for both pool and clone generation of expressive populations and cell lines.
• Execute a wide variety of molecular techniques including ddPCR for copy number and transcript analysis
• Prepare technical reports and presentations to communicate progress and data.
• Represent department function with external collaborators, vendors, and cross functional Sanofi colleagues.
  
  

About You

BASIC QUALIFICATIONS

• PhD (0-3years) in Biology, Molecular Biology, Cell Biology, Bioengineering, or related discipline, or Master’s degree in relevant discipline with > 4 years of relevant experience
• Strong technical background and attention to detail
• Self-motivated with excellent organization, time-management, and communication skills
• Demonstrated ability to work independently and as member of a team while adhering to timelines.
• Strong technical background and attention to detail
• Self-motivated with excellent organization, time-management, and communication skills
• Demonstrated ability to work independently and as member of a team while adhering to timelines.
  
  

Preferred Qualifications

• Hands-on experience in molecular cloning, Golden Gate or Gibson assembly
• Mammalian cell culture experience in a pharmaceutical or biotechnology setting
• Genetic characterization method experience (such as ddPCR, qPCR)
• Gene Editing experience for Knock-Outs or Knock-Ins
• Flexibility to adjust to a fast-paced, goal-oriented environment and willingness to expand and broaden skillset.
  
  

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
  
  

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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