What are the responsibilities and job description for the Senior Associate Scientist/Scientist I, Downstream Process Development position at Scholar Rock?
Scholar Rock is a biopharmaceutical company that discovers, develops, and delivers life-changing therapies for people with serious diseases that have high unmet need. As a global leader in the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins and named for the visual resemblance of a scholar rock to protein structures, the clinical-stage company is focused on advancing innovative treatments where protein growth factors are fundamental. Over the past decade, the company has created a pipeline with the potential to advance the standard of care for neuromuscular disease, cardiometabolic disorders, cancer, and other conditions where growth factor-targeted drugs can play a transformational role.
Scholar Rock is the only company to show clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). This commitment to unlocking fundamentally different therapeutic approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. By harnessing cutting-edge science in disease spaces that are historically under-addressed through traditional therapies, Scholar Rock works every day to create new possibilities for patients. Learn more about the company’s approach at ScholarRock.com and follow @ScholarRock and on LinkedIn.
Summary of Position:
The Technical Operations Department at Scholar Rock is seeking a scientifically curious and motivated scientist in the Downstream Process Development group. The successful candidate is expected to be proficient in all aspects of the purification process and be comfortable working with a multifunctional team. Experience in early-stage process development consisting of chromatography, depth filtration, nano-filtration, and high concentration TFF development is preferred. The selected candidate will work alongside in-house scientists to advance existing projects through the development lifecycle and help start up new projects.
Proficiency in AKTA operation, TFF, VRF, data presentation, and design of experiment skills are key traits that will ensure success in this role.
\n- Design experiments to develop, optimize, and characterize acceptable purification processes for antibodies.
- Detailed documentation of all experimental studies
- Work closely with CDMO to support tech transfer and manufacturing activities.
- Technical presentation to greater TechOps team
- Educational background in Chemical Engineering, Biochemistry, Biotechnology, or related biological Sciences.
- Direct experience working with mAbs is preferred.
- BS with 3 - 6 years of experience
- MS with 2- 4 years of experience
- Ph.D. with 0 - 3 years of experience
Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
