Preclinical DMPK Design Lead

Are you an experienced DMPK scientist with expertise in drug discovery? Would you like to apply your expertise in a company that is accelerating innovative science and turning ideas into life-changing medicines? Join us to be part of the development of future treatments for Cardiovascular, Renal, and Metabolic diseases!

We are now recruiting a highly skilled and passionate scientist with expertise in Drug Metabolism and Pharmacokinetics (DMPK) or Medicinal Chemistry to join the DMPK Drug Design and Biotransformation team within the Early Cardiovascular, Renal, and Metabolism (CVRM) therapeutic area at AstraZeneca. The position is based at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden.

Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. The DMPK Drug Design and Biotransformation team is part of the DMPK department and based in AstraZeneca’s world-class R&D center in Gothenburg, Sweden. DMPK interacts with other functions in supporting CVRM projects all along the value chain, from target selection all the way to market launch and lifecycle management.

Accountabilities

With a true passion for DMPK and science, you will support our portfolio within the CVRM disease area. You will be the DMPK Design Lead and responsible for the delivery of the overall non-clinical DMPK to early drug projects from target selection to candidate drug selection. Responsibilities include:

• Lead DMPK activities to assess the compounds' properties associated with absorption, distribution, metabolism, elimination (ADME), and drug-drug interaction potential within agreed timelines and to the right quality

• Create and implement an ADME optimization strategy to ensure a candidate drug with optimal ADME properties

• Analyze and identify the main DMPK liabilities for new chemical series during the Lead Identification phase

• In collaboration with colleagues in key functions (medicinal chemistry, bioscience, and safety) influence chemical drug design to optimize the ADME properties of our future therapeutic drugs

• Use state-of-the-art in silico tools (e.g., physico-chemical models for DMPK predictions) in the design phase to enable synthesis of compounds with good DMPK properties

• Build open and honest collaborations with internal and external partners (for example global colleagues, CROs, universities, research institutes)

• Communicate scientific progress both externally and internally

Essential Skills/Experience

The successful candidate is expected to have a solid understanding of DMPK and chemistry to be able to provide expert advice and interpretation of complex drug discovery data.

• PhD or equivalent degree in relevant field

• In-depth understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds

• Experience on early efficacious human dose predictions

• Excellent interpersonal and communicational skills, and ability to work in cross-functional teams as well as independently

• Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts

• Excellent communication skills in English, both verbal and in writing

Desirable Skills/Experience

Experience in pharmaceutical R&D and/or design and delivery of DMPK strategies

At AstraZeneca, we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our combination of curiosity and courage drives us, inspired by the possibility of doing things that have never been done before. Empowered to step up, we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way.

If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then apply now!

Welcome with your application no later than March 16th.

Date Posted

03-mars-2025

Closing Date

16-mars-2025

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.