Director, DMPK

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.

For more information see: www.septerna.com.

• Contemporary expertise in all aspects of modern DMPK approaches and ability to set overall company DMPK strategy, ranging from screening criteria for early-stage projects through candidate selection and potentially, early clinical development


• Extensive experience acting as a lead DMPK cross-functional project representative and ideally also Project Team Leader experience


• Demonstrated ability to independently design studies to assess the potential for drug absorption, metabolic stability, protein/tissue binding, and drug-drug interactions


• Drug discovery experience with multiple target classes, drug localization (e.g. CNS), and routes of administration is preferred


• Cross-functional appreciation for medicinal chemistry, computational modeling, assay development, and HTS, pharmacology, and preclinical toxicology


• A track record of successful management of external teams at contract research organizations is required.  Experience recruiting and mentoring PhD-level scientists is preferred


• Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings, and strong collaboration, leadership, and organizational skills.


• The successful candidate will be motivated to discover new disease-modifying therapeutics for patients and enjoy working in a fast-paced dynamic team environment

The anticipated salary range for candidates who will work in South San Francisco, CA is $220,000 - $240,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.