What are the responsibilities and job description for the Senior Scientist, Preclinical position at Skills Alliance?
About Our Company :
We are a stealth-mode biotechnology company harnessing the latest advancements in genetic medicine to develop transformative treatments for human diseases. Our mission is to leverage these cutting-edge tools to address widespread conditions, aiming to treat or cure diseases that affect large patient populations. To achieve this, we are pioneering therapeutics that target and regulate multiple genes at the DNA, RNA, and protein levels in vivo. We foster a dynamic and collaborative environment where our team can excel scientifically while bringing their authentic selves to work. We are seeking passionate and innovative individuals to join our growing team.
About the Role :
As a Sr Scientist reporting into the Head of Preclinical, you design, execute, and analyze experiments from therapeutic target evaluation to developmental candidate nomination. This position will be leading from the bench, and you will be working in close collaboration with our therapeutic program and platform technology teams, you will :
Execute experiments to identify lead candidates and optimize them to improve efficacy and safety of the platform.
Demonstrate therapeutic proof-of-concept, including identifying and onboarding disease-specific in vitro and in vivo models.
Develop in vivo delivery approaches for candidate therapies using AAV, LNP, or other platforms.
Demonstrate the potency, specificity, and targetability of our gene editing tools in the context of the therapeutic programs.
Coordinate assay development and execution of bioanalytical assays and other study read-outs, working with both internal and external resources.
Manage, oversee, train, and mentor scientists and research associates and foster a collaborative environment within the team and with external partners.
In all cases, you will ensure that study design and properly documented and align with the company's research goals, timelines, and budgets.
Requirements :
- A Ph.D. in neuroscience, pharmacology, physiology, drug delivery, genetics or a related life sciences discipline, with at least 5 years of drug development experience.
Experience solving complex scientific problems
In-depth knowledge of CRISPR-Cas or similar gene editing tools for therapeutic applications
In depth knowledge of iPSC-derived models in drug development and experience in applying these models to in vitro studies
Strong leadership abilities, with experience in managing scientific teams and fostering collaborative internal and external research environments. Demonstrated ability to work closely with senior leadership to ensure research efforts align with organizational strategy.
Ability to think creatively and drive for success in a fast paced and agile work environment.
Preferred Qualifications :
Demonstrated ability to work in multi-disciplinary teams to achieve experimental objectives
Experience working with gene editing and / or gene therapy applications, including refinement of core technology for specific targets.
Experience working in dynamic startup and / or small company environments that necessitate pitching in and assisting with a wide variety of important tasks.
A desire to create effective policies and procedures from the ground up.
