What are the responsibilities and job description for the Sr. Scientist-Principal Scientist position at Society of Exploration Geophysicists?
Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries and in vitro human lymph node cocultures for generating antigen-specific B-cells. We are seeking a Senior Scientist – Principal Scientist, Antibody Engineering to join our Antibody Screening group. As part of the Prellis Therapeutic Antibody Engineering team, you will report to the Director of Antibody Screening with accountability for engineering of development candidates, leading with a fully collaborative spirit, drive, enterprise mindset, and a team-centric and inspiring attitude. The ideal candidate will have a strong background in molecular biology, protein engineering, and a deep understanding of antibody and protein structure-function relationships.
Key Responsibilities :
- Oversee the design and development of novel antibody therapeutics, focusing on enhancing specificity, affinity, stability, and manufacturability
- Lead the conceptualization, design, and cloning of innovative bispecific or similar multi-specific antibody formats, including dual targeting and crosslinking capabilities
- Lead the construction of expression vectors and the production of reagent proteins and recombinant antibodies in various systems (e.g., mammalian, bacterial, insect)
- Utilize computational tools and modeling techniques to predict and optimize antibody-antigen interactions and structural stability
- Analyze experimental data and present findings to cross-functional teams and senior management.
Qualifications :
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