What are the responsibilities and job description for the Senior Scientist, Antibody Engineering position at Soleil Labs, LLC?
Senior Scientist Antibody Engineering
March 2025
Department: Technology
Work Location: Corporate Headquarters (South San Francisco)
Position Summary:
Join our innovative team at TCG Labs-Soleil as an antibody engineering expert! We are seeking a highly skilled and motivated scientist to lead and advance our antibody engineering capabilities within the cutting-edge Biologics Technology Group. In this pivotal role, you will develop and optimize antibody-based therapeutics while integrating computational and structural insights. You will collaborate cross-functionally with scientists across research and early development to drive technical excellence and support our growing pipeline of protein and antibody-based therapeutics.
Responsibilities:
• Directly contribute to the therapeutic pipeline by developing and optimizing antibody engineering strategies, including humanization, affinity maturation, bispecific and multispecific antibody design, and innovative molecular formats.
• Evaluate and implement cutting-edge antibody display technologies (e.g., phage, yeast, or mammalian display) to enhance discovery and screening capabilities.
• Collaborate closely with protein sciences, structural biology, and bioinformatics teams to integrate computational design with experimental validation.
• Drive technology innovation by staying current with emerging trends in antibody engineering and incorporating advances into the team’s workflows.
• Troubleshoot and resolve complex technical challenges related to in vitro antibody discovery, engineering, and characterization.
• Work cross-functionally with internal teams and external partners, CROs, and academic collaborators to expand antibody engineering capabilities.
• Design, implement, and analyze experiments efficiently, delivering data-driven insights that inform pipeline decisions.
Qualifications:
• Ph.D. with 5 years of postdoctoral or industry experience or M.S. with 10 years of industry experience in antibody discovery, engineering, biochemistry, structural biology, or related fields within biotech or pharm.
• Deep expertise in in vitro antibody discovery and optimization, including synthetic and immune library construction for lead identification and optimization.
• Proficiency in phage, yeast, or mammalian display technologies for antibody discovery, optimization and affinity maturation.
• Strong problem-solving skills with the ability to troubleshoot complex molecular and biochemical challenges.
• Demonstrated ability to prioritize tasks and manage multiple projects in a dynamic, fast-paced environment.
• Meticulous attention to experimental detail, adept at multitasking and managing concurrent experiments without compromising quality.
• Excellent oral and written communication skills, with a track record of presenting scientific findings and contributing to publications or patents.
• Strong team player with the ability to lead cross-functional collaborations and with flexibility to adapt to new scientific domains and quickly acquire new techniques.
Company Overview
TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.
For more details, visit TCGLSoleil.com and follow us on LinkedIn
EEO Statement
TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to contact@tcglsoleil.com.
Benefits and Compensation
TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.
The anticipated salary range for fully qualified candidates applying for this role will be $126,500 - $180,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.
Staffing Agencies
TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees. Inquiries must be sent to contact@tcglsoleil.com with the Subject Heading: Staffing Agency Request.
Salary : $126,500 - $180,000
