Program Lead, PPM

Summary:

Solid Biosciences is a life science company focused on advancing a portfolio of neuromuscular and cardiac programs, including potential gene therapy candidates for the treatment of Duchenne muscular dystrophy, Friedreich’s ataxia, catecholaminergic polymorphic ventricular tachycardia (CPVT), and other fatal cardiac diseases. Founded by individuals directly impacted by these conditions, Solid’s mission is to improve the daily lives of patients living with devastating disorders. By bringing together expertise in science, technology, disease management, and patient care, Solid aims to serve as a center of excellence across a range of serious diseases.

Position Summary:

The Program Lead will report to the Vice President of Portfolio and Program Management. In this role, you will lead and manage genomic medicine programs for the treatment of neuromuscular and cardiovascular diseases from discovery through launch. This position is critical to ensuring that project activities are strategically planned, well-executed, and delivered on time and within budget. The Program Lead will drive cross-functional coordination, serve as the primary point of contact for program stakeholders, and champion program goals to internal and external partners.

Key Duties & Accountabilities:

Develop and Drive Program Strategy

• Establish an integrated program strategy, leveraging functional expertise to define objectives, milestones, and success criteria.
• Prepare the program charter (scope, objectives, timelines, success criteria, and risks) for approval by senior leadership.

Plan and Execute Program Deliverables

• Create a detailed Program Execution Plan, ensuring all program elements—such as scientific, regulatory, manufacturing, and financial components—are integrated and aligned with the program charter.
• Oversee the day-to-day execution of the program, coordinating resources and tracking progress against key milestones.

Facilitate Governance and Decision-Making

• Lead stage-gate and phase-gate reviews in collaboration with cross-functional teams, ensuring timely, data-driven decisions.
• Conduct program close-out meetings and ensure lessons learned are documented and applied to future initiatives.

Risk Management and Resource Allocation

• Proactively identify, mitigate, and communicate program risks and proposed solutions, providing clear rationale for continued or increased investment.
• Partner with functional leads to prioritize and resolve resource constraints, escalating issues when necessary to maintain program timelines.

Cross-Functional Leadership and Engagement

• Serve as a credible and enthusiastic champion for assigned programs while maintaining an objective, data-driven perspective.
• Foster a motivated, collaborative project team culture that drives accountability and success.

Core Competencies Required:

• Strong knowledge of drug development processes and stage-gate governance.
• Excellent organizational skills with the ability to manage multiple projects and priorities.
• Proven ability to communicate effectively with senior leadership, scientific experts, and external partners.
• Ability to influence without direct authority and foster collaboration in a matrixed environment.
• Strategic thinker with strong analytical and problem-solving skills.

Knowledge: Education, Experience, & Skills:

• MS or PhD in Molecular Biology, Genetics, Cardiovascular Biology, or a related field.
• Minimum of 12 years (MS) or 8 years (PhD) of experience in gene therapy research and development, with a focus on AAV, or gene editing technologies.
• Expertise in neuromuscular or cardiovascular biology, or rare genetic diseases, particularly cardiomyopathies.
• Excellent communication and interpersonal skills, with the ability to work collaboratively across disciplines.
• Prior experience in a pharmaceutical or biotech setting focused on rare diseases or gene therapy development.
• Familiarity with regulatory requirements and experience with BLA/MAA submissions preferred.

Travel Commitment: Some Travel Required

Role Location: (HQ, Hybrid, Remote, NC, etc.)

Role can be Remote or Hybrid