What are the responsibilities and job description for the Principal Scientist, Protein Sciences position at Synolo Therapeutics?
About Synolo Therapeutics :
Synolo Therapeutics, an early-stage biotechnology company launched by RA Capital, is pioneering the development of precision-targeted immunotherapies. Powered by computational protein design and proprietary technologies which yield biological data sets at unprecedented scale and resolution, we are building a pipeline of first-in-class multi-specific biologics with novel functionalities. Synolo was founded by pioneers in the field of protein design and engineering, synthetic biology, DNA sequencing, immunology, and biologics drug discovery and development.
About RA Capital :
RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. TechAtlas' analyses are captured in a unique collection of competitive landscapes, or ‘maps’, that identify competitive therapeutics, diagnostics, research tools, and / or technological capabilities in a given area.
About the Role :
Synolo Therapeutics is seeking an innovative, self-motivated, and team-oriented Principal Scientist in Protein Science to drive the discovery and development of novel medicines in a fast-paced startup environment. In this role, you will leverage your expertise in protein expression, purification, and characterization to establish and manage in-house capabilities, as well as generate and characterize lead product candidates. Your deep knowledge of Protein Science will be instrumental in supporting cross-functional teams and advancing our drug discovery and development programs. As a key member of our growing and dynamic team, you will play a vital role in our mission to develop novel therapeutics to improve patients’ lives.
Key Responsibilities :
- Build and manage in-house capabilities of protein expression in mammalian cells (e.g. CHO) and E. coli, as well as protein purification, to support research activities, project goals, and platform development
- Design and execute experiments to express multi-specific biologics
- Purify lead candidates using various liquid chromatography techniques
- Conduct biochemical and biophysical characterization of purified leads
- Evaluate protein solubility, stability, and formulation of purified leads
- Perform developability studies on lead panels of molecules using biophysical methods
- Analyze and communicate experimental results to cross-functional teams to foster collaboration and drive project success
- Provide mentorship and guidance to junior team members as needed
Qualifications & Skills :
Education & Experience :
Preferred Experience :
At Synolo Therapeutics, we are committed to fostering a diverse and inclusive work environment where all individuals are valued and treated with dignity. We believe that diversity drives innovation and strengthens our ability to make a meaningful impact through our work. We are committed to being an equal opportunity employer who ensures that all qualified applicants receive equal consideration for employment without regard to neurodiversity, race / ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity / expression, age, disability, genetic information, military service, covered / protected veteran status or any other federal, state or local protected class. #J-18808-Ljbffr
