Scientist/Senior Scientist -- Biologics Discovery & Engineering

About Synolo Therapeutics:

Synolo Therapeutics, an early-stage biotechnology company launched by RA Capital, is pioneering the development of precision-targeted immunotherapies. Powered by computational protein design and proprietary technologies which yield biological data sets at unprecedented scale and resolution, we are building a pipeline of first-in-class multi-specific biologics with novel functionalities. Synolo was founded by pioneers in the field of protein design and engineering, synthetic biology, DNA sequencing, immunology, and biologics drug discovery and development.

About RA Capital:

RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. TechAtlas' analyses are captured in a unique collection of competitive landscapes, or ‘maps’, that identify competitive therapeutics, diagnostics, research tools, and/or technological capabilities in a given area.

About the Role:

Synolo Therapeutics is seeking an innovative, self-motivated, and team-oriented Scientist or Senior Scientist in Biologics Discovery & Antibody Characterization with a passion for discovering and developing novel medicines and who thrives working in a fast-paced startup team. In this role, you will help conduct in-house biologics discovery and characterize multi-specific antibody drug candidates. You will support our cross-functional teams and be a key contributor to our drug discovery and development programs. As a member of a rapidly growing and very engaged team, you will help us in our mission to develop novel therapeutics to improve patients’ lives.

• As a member of our in-house biologics team, drive research activities, achieve project milestones, and advance platform development for biologics discovery and multi-specific antibody engineering.
• Analyze antibody sequences and design antibody libraries using immune or synthetic sources (including ML or AI-generated datasets), followed by experimental isolation of antibodies with desired properties.
• Optimize multi-specific antibody leads through humanization or affinity maturation.
• Engineer and refine multi-specific antibody constructs to maximize functionality.
• Communicate findings to project teams and cross-functional groups to foster collaboration and drive project success.

• Comprehensive knowledge of canonical antibody sequence classes and structures, including experience with alternative formats such as scFv’s and VHH’s.
• Practical expertise in yeast or phage display techniques for antibody engineering, encompassing library construction, panning/sorting, and sequence analysis, OR hands-on experience with B cell sorting/sequencing workflows.
• Proficiency in next-generation sequencing (NGS) and its applications for B cell workflows and library selections.
• Strong communication and interpersonal skills with the ability to cultivate collaborative relationships within cross-functional teams.

• Scientist: PhD in Biochemistry, Molecular Biology, Biomedical or Chemical Engineering, or a related field with 0-3 years of relevant experience, MS with 5 years, or BS/BA 8 years of relevant industry experience.
• Senior Scientist: PhD with 3 years of relevant experience, MS with 8 years, or BS/BA with 12 years of relevant industry experience.
• Title will be commensurate with experience.

• Familiarity with immunization protocols and downstream antibody discovery workflows.
• Experience with biophysical characterization techniques such as BLI, SPR, DSF, and HPLC-based methods.
• Experience in the biotech industry, with a focus on biologics discovery.

At Synolo Therapeutics, we are committed to fostering a diverse and inclusive work environment where all individuals are valued and treated with dignity. We believe that diversity drives innovation and strengthens our ability to make a meaningful impact through our work. We are committed to being an equal opportunity employer who ensures that all qualified applicants receive equal consideration for employment without regard to neurodiversity, race/ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.