Scientist (AKTA/Purification/Cell Culture/Nucleic Acid Preparation)

Summary

• The Biotherapeutics and Genetics Medicine department within Discovery Research is seeking a highly motivated research scientist to join in the Genetic Medicine (GM) group at Company Bioresearch Center.
• The client site, based in Worcester, MA, offers a unique setting where GM, Biologics drug discovery, development and manufacturing coexist in one location.
• Our team interacts with multidisciplinary groups across Company focused on developing therapies for Immunology, Neurology, Ophthalmology and Oncology diseases.
• As an integral member of the GM team this individual will perform research related to mRNA therapeutics to strength the platform and support various programs.
• The successful candidate is expected to have knowledge of RNA molecular biology, production, quality control, and cell-based assays.
• As one of the key team members, this individual will work with scientists across different functional groups and therapeutic areas to discover and develop next generation biologics through interrogation of RNA-related technologies.

Key Responsibilities:

• In vitro transcription to produce mRNA at different scales to support the platform development and therapeutic programs.
• RNA Purification using affinity chromatography (AKTA) and other strategies for purification.
• Quality control assays for mRNAs like electrophoresis, ELISA, qPCR, etc.
• Perform cell-based assays, such as cell culture, transfection, and flow cytometry.
• Work closely with the manager and cross-functional team members on multiple tasks with the ability to analyze, interpret, and present data.
• Assist in ordering reagents from internal and external suppliers and communicating with CROs.
• Generate reliable and reproducible data in a timely manner. Read and adapt scientific literature to accomplish assignments. Demonstrate broad and versatile technical expertise within discipline.
• Maintain electronic laboratory notebooks (ELN) in compliance with the Company Laboratory Notebook Policy.
• Stay updated and in compliance on all departmental and corporate training.

Key Qualifications:

• MS in molecular biology, biochemistry, biomedical engineering or related field with 0-2 years of experience in biotherapeutics or genetic medicine or BS with a minimum of 3-5 years of relevant industry experience.
• Hands-on experience with nucleic acid preparation, purification (AKTA), QC, and cell-based assays.
• Working knowledge of related tools/software (SnapGene, Prism, FlowJo, Excel, PowerPoint etc.).
• Self-motivated, hard-working, detail-oriented, resourceful, and able to work in a fast-paced team environment with demonstrated problem-solving skills.
• High-quality written and oral communication skills and the ability to excel in a collaborative environment.

Job Type: Contract

Expected hours: 40 per week

Benefits:

• 401(k)
• Dental insurance
• Health insurance
• Paid time off
• Vision insurance

Schedule:

• 8 hour shift
• Day shift
• Monday to Friday

Education:

• Bachelor's (Preferred)

Experience:

• nucleic acid preparation: 4 years (Preferred)
• purification (AKTA): 3 years (Preferred)
• cell-based assays.: 4 years (Preferred)
• ELISA, qPCR: 4 years (Preferred)
• Cell culture: 4 years (Preferred)
• Flow cytometry: 4 years (Preferred)

Ability to Commute:

• Worcester, MA 01602 (Required)

Work Location: In person