Senior Scientist - Antibody Discovery

Redmond

Company Overview:

SystImmune Inc. is a dynamic clinical-stage bio-pharmaceutical company headquartered in Redmond, WA. Our mission is to revolutionize cancer treatment by developing breakthrough-therapeutic multi-specific antibodies and ADCs. With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are committed to advancing innovative therapies from discovery through IND-enabling stages.

Job Summary:

We are seeking a highly skilled and motivated Senior Scientist to join our Antibody Discovery Group. The successful candidate will play a critical role in advancing our antibody discovery efforts through various techniques, including target analysis, immunogen design, B-cell sorting, flow cytometry, ELISA, and yeast library screening. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

Key Responsibilities:

• Perform in-depth analysis of potential targets, including clinical landscape, biology, protein structure, and literature review.
• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze and compare BCR sequences and immune repertoires.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Qualifications:

Education: Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field.

Experience:

• 3 years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry.
• 3 years of hands-on experience in yeast library preparation, culture, and screening.
• Knowledge of antibody structure is required; general knowledge of structural biology is a plus.
• Extensive knowledge of B-cell immunology and antibody development.
• Extensive knowledge of cancer immunology.
• Proven contribution to therapeutic antibody development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is also desirable.

Technical Skills:

• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• Expertise in molecular biology techniques related to yeast display libraries.
• Familiarity with data analysis software and statistical tools (e.g., FlowJo, OCTET, GraphPad Prism, Geneious Prime).

Soft Skills:

• Excellent problem-solving and troubleshooting abilities.
• Strong organizational and time management skills.
• Ability to work independently and as part of a team.
• Effective communication skills, both written and verbal.

Benefits:

• Competitive salary and performance-based bonuses.
• Comprehensive health, dental, and vision insurance.
• Retirement savings plan with company match.
• Opportunities for professional development and career advancement.
• Collaborative and inclusive work environment.

Join us in advancing cutting-edge clinical pharmacology research and contribute your expertise to our dynamic team!

Language Ability
Ability to read and comprehend simple instructions, short correspondence, and memos. Ability to write simple correspondence. Ability to effectively present information in one-on-one and small group situations to customers, clients, and other employees of the organization. Strong interpersonal, communication and collaboration skills to connect with internal and external CROs.

Math Ability
Ability to calculate figures and amounts such as discounts, interest, commissions, proportions, percentages, area, circumference, and volume. Ability to apply concepts of basic algebra and geometry.

Reasoning Ability
Ability to interpret a variety of instructions furnished in written, oral, diagram, or schedule form. Strong scientific, medical, and analytical abilities with innovative, solution-oriented style.

Computer Skills
Proficiency with Microsoft Word, Excel, and PowerPoint required. Proficiency with email required.

Certificates and Licenses
None required.

Work Environment:

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
This individual will work in a molecular biology laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. ‍

While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment.

The hiring pay range for this position is $90,000 - $140,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter to hr@systimmune.com