2025 U.S Summer Internship Program: Neuroscience Modeling & Simulation Intern

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Job Description

The DMPK&M Neuroscience modeling group develops mathematical models (such as PKPD and QSP) of disease progression and drug response to inform preclinical drug optimization, guide study design, and provide human dose predictions. We take in vitro data, animal data, and when available, natural history and clinical data to translate preclinical findings into predicted clinical responses. We work closely with bench scientists and clinical scientists to provide high quality support in early drug research and development.

Job Description:

This summer internship project involves developing mechanistic models to link pathological nucleotide expansion repeat dynamics to neurodegeneration and related biomarkers, building on existing models and data.

As an intern, you will:

• Calibrate and evaluate the ability of these models to describe disease progression
• Simulate interventions to investigate potential therapeutic benefit and biomarker responses
• Present your findings to teams within Takeda including modelers and neuroscience colleagues.

A successful intern will provide our neuroscience teams quantitative comparisons of how our intervention(s) may work depending on patient characteristics and timing of intervention, leading to higher quality human dose prediction strategy within DMPK&M.

Internship Development Opportunities:

• Exposure to how modeling and simulation can play a role in drug development in the preclinical and translational setting.
• Learn to understand different ways of working in the neuroscience modeling field.
• 'Customer' management (eg modeler and neuroscience colleagues)

Job Requirements:

• This position will be Hybrid and require 2-3 days in the Cambridge office per week.
• Must be a PhD candidate in Biomedical/Chemical Engineering, Applied Mathematics, or other discipline bridging mathematical modeling and biological systems.
• Prior experience with ODE-based mathematical modeling is required at a minimum.
• You must be able to build models in a programming language (e.g. MATLAB) and be able to communicate results to both modelers and non-modelers.
• Highly reliable and a strong team player
• Flexible with an attention to detail
• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
• Must be currently enrolled in a degree program graduating December 2025 or later
• The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 22nd) or (June 16th - August 29th) 
  • The intern must be able to commit to one of these time frames
• Able to work full time 40 hours a week during internship dates
• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

 Program Highlights:

• Hands-on experience with real projects and responsibilities
• Dedicated mentorship program pairing interns with experienced professionals
• Networking opportunities with industry professionals and fellow interns
• Internship events focused on professional and skills development
• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between December 18th and January 10th

For Location:

U.S. Hourly Wage Range:

$21.00 - $46.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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Job Exempt

Salary : $13 - $20