Scientist CryoEM

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Job Description

We are seeking a highly skilled and motivated PhD level CryoEM specialist to report into Takeda’s Structural Biology organization. The ideal candidate will possess a strong background in the field of structural biology and will use this expertise to generate data, interpret structures and provide insights that will advance Takeda’s drug discovery programs. A successful candidate will work with internal and external teams to execute structure-based efforts and protein production requirements as well as collaborate with cross-functional teams to progress Takeda’s pipeline.

The successful candidate will:

• Plan and execute gene-to-structure projects as well as generate target co-complex structures with small molecules and/or biologic proteins using in-house CryoEM capabilities and contract research organizations, including utilization of in-house hardware, software and database resources
• Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts and/or antibody design, optimization and characterization
• Work collaboratively on pipeline projects with an interdisciplinary team (biologists, medicinal and computational chemists, in vitro and in vivo pharmacologists, informatics scientists, DMPK, project management)
• Clearly communicate structural data, interpretation and insights to diverse audiences including structural biology group, project teams, department colleagues and senior leadership

Candidate qualifications include:

• PhD degree in a scientific discipline (Structural Biology, Biophysics, Biochemistry/Enzymology, Protein Chemistry) with 3 years direct experience utilizing CryoEM instrumentation, data generation and structure analysis; MS (5 years) or BS (10 years) candidates with CryoEM experience also considered
• Demonstrated track record of supporting high-quality structure determination and validation of protein and co-complex structures; experience in biotechnology or pharmaceutical companies contributing to drug discovery pipelines highly desirable
• Experience utilizing CryoEM and modeling software packages including but not limited to CryoSparc, Relion, Coot, ChimeraX, PHENIX, Schrodinger software, PSILO or other structure deposition databases
• Proficiency in operation of cryoEM hardware, including alignment, maintenance and use of cryoTEMs (ThermoFisher or Jeol) and grid plungers (Vitrobot, Chameleon) highly desirable
• Extensive knowledge of and experience in protein production including construct design/protein engineering, protein expression systems (bacterial, insect, mammalian systems), protein purification techniques and protein characterization methods
• Experience with small molecule micro electron diffraction, protein crystallography methods and structure determination, biophysical techniques (SPR, ITC, DLS, etc), and/or membrane protein production and crystallization highly desirable
• Passion for learning and advancing structural biology capabilities and drug discovery pipelines, including proactive investigation of new techniques and capabilities, advanced software / hardware and innovative experimental approaches
• Ability to work collaboratively in a fast-paced, matrixed environment with a collaborative and proactive mindset, motivated by a desire to create therapeutic molecules for the benefit of patients in need worldwide

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Cambridge, MA

U.S. Base Salary Range:

$108,500.00 - $170,500.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Cambridge, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

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