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Chief Operating Officer (COO)

Tbwa Chiat/Day Inc
Menlo, CA Full Time
POSTED ON 4/18/2025
AVAILABLE BEFORE 5/13/2025

BillionToOne is a next-generation molecular diagnostics company dedicated to developing powerful and accurate diagnostic tests that are accessible to all. Our innovative QCT molecular counting technology significantly enhances the resolution of disease detection using cell-free DNA by over a thousandfold. This groundbreaking technology is integral to our product offerings, including one of our flagship products, Unity Complete, the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Leveraging the same molecular counting technology, we've expanded our impact into oncology in 2023 with a pioneering liquid biopsy test, Northstar, that combines treatment selection with monitoring. To date, over 500,000 patients have benefited from our innovative and precise diagnostic tests , and our Annual Recurring Revenue (ARR) has grown from $0 to $125 million in the last ~4 years.

BillionToOne has successfully raised close to $400 million in funding, with a notable $130 million Series D round completed in June 2024, resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. BillionToOne has recently been recognized by Forbes as one of America's Best Startup Employers for 2024 , highlighting the company's exceptional work environment and commitment to innovation.

Our team has grown significantly and we now proudly employ over 400 highly skilled individuals. Despite substantial growth, we have successfully maintained the unique culture that has defined BillionToOne from inception, continuing to cultivate a team that is not only diverse and passionate but also innovative. Headquartered in Menlo Park, California, with an additional facility in Union City, California, BillionToOne remains at the forefront of significant advances in molecular diagnostics, evidenced by the recent announcement of clinical outcomes data for its Unity Fetal Risk Screen and new advancements in cancer diagnostics.

We are looking for a highly impactful Chief Operating Officer (COO) role that will oversee non-R&D and non-commercial day-to-day operations. This pivotal role will establish the operational systems necessary to scale the company from 500 to 2000 employees and grow revenues from $150M ARR to $1B ARR over the next five years, while maintaining our high standards of operational excellence and strong company culture. The COO is a hybrid position and reports directly to our CEO.

Responsibilities :

  • Collaborate closely with the CEO and the rest of the executive team to implement and drive the company goals
  • Lead and manage functions including Laboratory Operations, Quality, IT, People Ops, and, over time, Legal and Reimbursement
  • Drive the implementation of robust operational processes, systems, and scalable solutions to support BillionToOne’s next chapter of 10x growth
  • Ensure operational practices align with BillionToOne’s mission and values, maintaining a strong transparent culture
  • Facilitate a culture of continuous improvement and operational excellence, emphasizing recruiting and retention of talent, maintaining an impressively high bar for employees, and implementing robust learning & development processes to enable their potential
  • Implement processes to maintain and improve high quality in operations while achieving operational excellence and continuous improvements in COGS
  • Support the company’s preparation to go public, ensuring profitability and strong financial management

Requirements :

  • Proven experience as either GM of a large division or SVP of Global Operations at a large-cap company (market cap $10B )
  • Experience overseeing at least $100M P&L and 500 employees
  • Experience managing a hypergrowth division / organization (at least 50% YoY revenue growth)
  • Demonstrated success in leading diverse functions, including laboratory operations, quality, people operations, and IT / IS
  • Expert in instituting company-wide initiatives that drive operational effectiveness, scalability, and a strong culture
  • Diagnostics experience is essential; CLIA experience is preferable
  • Working with a team of ‘rockstars’ who bring out the best in everyone
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousand patients
  • For this position, the base salary is $300,000 per year with an annual bonus at plan of 30% and stock options valued at $1M / year, for a total compensation of $1.4M per year.

    BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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