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Optical Engineer - Advanced Light Sheet Microscopy

Tbwa Chiat/Day Inc
San Francisco, CA Full Time
POSTED ON 2/14/2025
AVAILABLE BEFORE 5/2/2025

Optical Engineer - Advanced Light Sheet Microscopy

The Chan Zuckerberg Biohub San Francisco CZ Biohub SF ) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering / hacking / building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

The Opportunity

The Royer Group, a lab led by Loic Royer at the Chan Zuckerberg Biohub, is a multidisciplinary team of computer scientists, optical engineers, and biologists, fascinated by a simple but incredibly complex question : How do organisms develop from a single cell into a fully functional body with billions of self-organizing cells that form tissues and have different functions? Our bet is that solving this question will require expertise across Computer Science, Microscopy, and Biology. We aim to build a Time-Resolved Multi-Dimensional and Multi-Modal Atlas of Vertebrate Development using Zebrafish as a model organism. To attain this goal, we design and build novel state-of-the-art light-sheet microscopes, as well as conceive deep-learning-based image processing and analysis algorithms.

You will

  • Assemble and build advanced optical microscopes from off-the-shelf or custom-designed optical / mechanical / electrical components
  • In collaboration with application engineers and scientists, automate instrument control and data acquisition pipeline
  • Conduct proof-of-principle imaging experiments to evaluate microscope performance
  • Maintain, troubleshoot and optimize the performance of existing microscopes in the lab
  • Maintain accurate documentation of microscope hardware designs and standard operating procedures
  • Train users to operate the microscope, and collaborate with biologists in conducting live imaging experiments

You have

  • Bachelor's or Master’s degree in Optical Engineering, Electrical Engineering, Applied Physics, and / or related field
  • Minimum of 1 year hands-on experience in building and aligning optical imaging / microscopy systems
  • Solid understanding of geometric optics, physical optics, Fourier optics, and imaging theory
  • Proficient in common optical / electrical test and measurement tools
  • Experience with CAD design software (e.g., Solidworks, Onshape)
  • Proficient in using Python for data / image analysis and instrumentation control
  • Willingness to learn new methods, protocols, and technologies
  • Collaborative spirit and teamwork skills
  • Nice to have -

  • Hands-on experience in fluorescence microscopy (ideally light-sheet microscopy)
  • Experience with live imaging of cells, organisms, or small animals
  • Experience with optical design and simulation software (e.g., Zemax, Code V)
  • Experience with electronics and PCB design
  • Co-authorship in preprints or peer-reviewed publications
  • Compensation

    New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. Your recruiter can share more about the specific pay range during the hiring process.

    What We Provide

  • Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease
  • A collegial and collaborative environment consisting of diverse expertise
  • Access to collaborators, resources, and facilities at our three partner universities (Stanford, UC Berkeley, and UC San Francisco) and at partner organizations in the Bay Area and beyond
  • Competitive compensation and benefits commensurate with experience
  • We offer a robust benefits program that enables the important work Biohubbers do every day. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off, and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.

    The CZ Biohub Network is an equal opportunity employer committed to diversity of thought, ideas, and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution.

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