Senior Scientist, RNA Rewriter for Hematopoietic Stem Cells

Your experience includes…

•    PhD with 5 years of relevant academic or industrial research experience.
•    Extensive experience in in vitro and in vivo manipulation and analysis of HSC.
•    Extensive experience with multicolor FACS isolation of HSC and relevant hematopoietic populations.
•    Proficient with various NGS techniques including amplicon sequencing, and sc sequencing.
•    Quick learner, critical mind, and team player, comfortable in a fast-paced environment.
•    Strong attention to detail with the capability to work on multiple projects simultaneously.

You are interested in… 

•    Designing and executing in vivo validation of selected payloads in mice and NHP.
•    Processing of primary bone marrow samples, including mouse, human and NHP origin, including multicolor flow cytometry and FACS to sort hematopoietic populations of relevance.
•    NGS libraries preparation and analysis of editing outcomes.
•    Design and execution of in vitro and in vivo experiments aimed at establishing HSC properties (fitness, multilineage differentiation) after editing.
•    Working independently and as part of a team to design, plan, execute and troubleshoot complex experiments that support Tessera’s research efforts for the development of RNA gene writers for Hematopoietic Stem Cells (HSCs)
•    Designing and testing iterations of RNA gene writers and templates in vitro on primary human HSC using electroporation or LNP transfection.
•    Execution of IND-enabling experiments in vivo aimed at validating efficacy and safety of drug products in primary bone marrow samples from mice, human and NHP origin.
•    Documenting, presenting, and communicating scientific findings to stakeholders.

About you: 

You are an innovative and dedicated Scientist with a passion for advancing genetic medicines applied to the hematopoietic system. You thrive in fast-paced environments and enjoy collaborating within multidisciplinary teams. With extensive experience in manipulation and analysis of Hematopoietic Stem Cells, you will contribute to the development and validation of novel RNA gene writers to advance our in vivo programs (from in silico design to in vivo testing in different animal models). Previous experience with optimization of genome editing technologies for use in stem cells and in vivo models of sickle cell disease is a plus.

Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence. 

Meet your Manager:
All inquiries regarding the posted position should be directed to the Talent Partner (see below). Interested individuals must apply directly to be considered for the opening. 

Giulia Schiroli, PhD
Associate Director of RNA Rewriter team for Hematopoietic Stem Cells and lead of the research program for in vivo correction of sickle cell disease.

Meet our Leadership Team and Board of Directors 
 
Meet your Talent Partner:

Narissa Furtado-Cordeiro: Manager, Talent Acquisition

Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits currently include group medical, vision and dental coverage, group life and disability insurance, 401(k) with company contribution, tuition reimbursement, and much more.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with Tessera regarding a reasonable accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied, please contact the recruiter or Accommodations@tesseratx.com

Recruitment & Staffing Agencies:  Tessera Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Tessera Therapeutics or its employees is strictly prohibited unless contacted directly by Tessera Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Tessera Therapeutics, and Tessera Therapeutics will not owe any referral or other fees with respect thereto.