What are the responsibilities and job description for the Postdoctoral Training Fellow: In Situ Structural Biology position at The Institute of Cancer Research?
Under the leadership of Professor Sebastian Guettler, we seek a Postdoctoral Training Fellow to join the Structural Biology of Cell Signalling Group at ICR's Chester Beatty Laboratories, Fulham Road in London. The new Team Member will investigate the structure of macromolecular assemblies in situ, using cryogenic fluorescence microscopy and cryo-electron tomography (cryo-ET), with a particular emphasis on the mechanisms of the ADP-ribosyltransferase tankyrase. The Team Member will be supported by ICR's Light and Electron Microscopy Facilities and benefit from recent investments into in situ structural biology at the ICR. General information on Postdocs at the ICR can be found here.
Key requirements
The successful candidate must have a PhD in a biological science or any other area relevant to the laboratory's research. Experience in cryo-EM is essential, and experience in in situ structural biology approaches is desirable.
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years.
Department / Directorate Information
The candidate will work in the Structural Biology of Cell Signalling Group within the ICR Division of Structural Biology headed by Professor Laurence Pearl and Professor Sebastian Guettler. The Division features state-of-the-art structural biology infrastructure and a vibrant research community. Its Electron Microscopy Facility is equipped with a 200-keV Thermo Fisher Scientific Glacios TEM with a Falcon 4i detector. The ICR further has access to Krios microscopes via the Electron Bio-Imaging Centre (eBIC) at the Diamond Light Source and the London Consortium for Cryo-EM (LonCEM). Recent investments include equipment for in situ structural biology, particularly a Leica EM GP2 plunge freezer, an EM ICE high-pressure freezer, an Ultracut ultramicrotome with an FC7 cryo-chamber, a STELLARIS 5 cryo-confocal microscope, and a Thermo Fisher Scientific Selectris energy filter for ICRs Glacios TEM. FIB-SEM access is available through eBIC. An initiative to establish FIB-SEM at the ICR is underway.
