Research Assistant III | Molecular & Cell Biology | Hinson Lab

Research Assistant III Hinson Lab Farmington, CT The Hinson lab is seeking an independent, highly-motivated individual who wants to join our multidisciplinary team focused on the development of new genetic models and genome editing therapeutics for inheritable forms of cardiovascular disease. The ideal candidate would have prior rigorous training in cell and molecular biology including molecular cloning, immunoblotting, and basic next-generation sequencing assays such as amplicon sequencing and/or RNA-sequencing. Additional skills that would be of particular interest to the position include pluripotent stem cell handling/differentiation and mouse cardiac physiology methods and analyses including echocardiography. The candidate will be supported by several NIH grants to utilize our laboratories human cardiac microtissue platform and mouse models to identify new therapies for genetic forms of heart failure. The Hinson lab at the Jackson Laboratory for Genomic Medicine and UConn Health studies human cardiovascular disorders especially heart failure using a combination of approaches including genome editing, pluripotent stem cell technology, mouse models, genomics assays, and tissue engineering. We are a highly-collaborative multi-disciplinary team that includes expertise in genome biology, computation biology, tissue engineering, cardiac physiology and clinical cardiovascular medicine. Requirements  Proposes alternative research methods, techniques and initiatives demonstrating knowledge of other scientific areas and related research  Demonstrates scientific knowledge and analytical skills to monitor, modify, and design the research process. Designs, modifies, and troubleshoots highly specialized equipment.  Independently expands scope of literature search to support and/or propose alternative experimental methods, procedures and/or techniques.  Gathers information to prepare budget and proposes estimates for acquisition of supplies and equipment  Analyzes and resolves variations in complex tests, experiments and procedures; designs and implements modifications and changes to techniques, procedures and quality control measures  Leads multiple, concurrent projects and/or multi-faceted projects; directs others in making modifications  Evaluates documentation of results; leads efforts to modify and adapt research methodologies in collaboration with others; ensures compliance with regulatory standards.  Manages laboratory resources, may include budget and personnel; establishes priorities in the use of resources including space, field, equipment and/or facilities.  Understands research goals thoroughly; can instruct and inform others about past and future research directives. Also coordinates with outside collaborators to open new avenues or points of interest of research. Shows a willingness to teach as well as be taught.  The RA III may have direct supervisory responsibilities and is accountable to ensure the effective training and development program for assigned personnel and to identify and develop staff. The RAIII is responsible to develop training and development programs to strengthen technical and management skills. Qualifications Bachelor's degree in cell biology, molecular biology, genetics, or related field of study Prior research experience in at least two of the following areas: pluripotent stem cell biology and differentiation, cellular physiology, next-generation genome sequencing assays, tissue engineering especially involving engineered cardiac tissues, and in vivo cardiac physiology and function especially in mouse models including echocardiography. Experience in single cell technologies for transcriptomics, flow cytometry (or other forms of cytometric analyses), and confocal microscopy particularly live cell imaging is also desirable. Excellent writing and communication skills, able to work independently and effectively with other members in a productive team Experience with R, Python or similar statistical package is helpful, as well as experience with clustering, pathway, genetic and genomic data analyses and bioinformatics We are a diverse and inclusive research group, aspiring to produce top science and scientists through attentive and progressive mentoring and interdisciplinary teamwork. Pay range: $51,677 - $67,180 About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Bar Harbor: The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. Ellsworth: The Charles E. Hewett Center in Ellsworth, Maine, is a state-of-the-art facility that serves researchers world wide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine’s fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year-round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants. Farmington: JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports. Sacramento: The JAX® Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two-hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation’s Farm to Fork movement, and offers excellent restaurants, gastro-pubs, wineries, theaters, and museums. Outdoor activities are plentiful: Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year. Augusta: JAX’s Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.