Research Technologist - Medical Sciences - Cancer Institute

The Penn State College of Medicine, Cancer Institute (PSCI), in Hershey, PA is recruiting for a full-time Research Technologist in the laboratory of Dr. Patrick Ma (Associate Director of Translational Research). The Ma Lab focuses on translational cancer research in thoracic oncology with emphasis in mechanisms of drug resistance in targeted therapy, and immunotherapy. Other areas of research focus include PDX preclinical modeling, predictive biomarkers, epigenetic regulation of tumor reprogramming, and single cell molecular-omics analysis. The responsibilities and requirements include:

• Design and perform experiments requiring highly specialized techniques in cancer cellular/molecular biology and cancer immunology, under the guidance and direction of Dr. Ma. These will consist of:

• In vivo studies using both immunocompromised (e.g. nude mouse, NSG mouse) and immunocompetent mouse models of cancer, including transgenic models
• Molecular and cellular assays such as MTS viability assay, western blot, soft agar assay, cell invasion assay
• Single cell analysis e.g. 10x Genomics Chromium, IsoPLexis IsoLight proteomics platforms
• Molecular and cellular immunology methods and techniques
• Isolation and analysis of tumor cells and tumor infiltrating lymphocytes
• Quantification of gene expression by qRT-PCR and preparation of samples for RNAseq and other genomics, proteomics and epigenomics profiling experiments
• Translational studies involving archival and fresh human tumor biopsied tissues and cell lines, and establishment of preclinical cell lines (including 3D spheroid culture), animal models using patient-derived xenografts (PDX) method
• Management of clinical-pathologic database on translational research project projects involving patients' tissue and blood samples
• Perform multicolor flow cytometry experiments
• Attend and present at lab meetings and selective internal and external scientific conferences

• Perform manual or computer-assisted data analysis, including the use of bioinformatics software; accurately record procedures used and results obtained from all experiments conducted; summarize results to assist in manuscripts preparation targeted towards high-visibility research journals or posters targeted towards scientific conferences.
• Assist in lab stewardship, which may include maintaining cell cultures, manages safety assessment documents and databases, maintaining lab and equipment, keeping accurate inventory of lab assets, ordering supplies, and follow-up on working conditions of lab equipment and usage.
• Develop new techniques and protocols by consulting various sources (articles, faculty, manufacturers, etc.). Maintain professional growth and development by reading current research literature, attending courses, seminars, and presenting research at conferences.
• Advise, educate and train other lab personnel on area(s) of expertise.
• Excellent oral and written communication skills, interpersonal skills and team-player capacity.

Experience and proficiency in relevant techniques, including processing human samples, mouse modeling, and in vitro molecular and functional studies, are required. Expertise in cancer immunobiology/immunotherapy would be highly desirable.

TYPICAL EDUCATION & EXPERIENCE

1 years related experience

Bachelor's Degree or higher in appropriate disciplines (e.g. biology, biomedical engineering, biomedical sciences)

Or an equivalent combination of education and experience

This is a limited-term position funded for one year from date of hire, with possibility of refunding.

The following clearances must be successfully completed for this position:

• Pennsylvania State Police Criminal Background Check
• Pennsylvania Child Abuse History
• Federal Bureau of Investigation (FBI) Criminal Background Check

The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms. We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusive excellence as a core strength and an essential element of our public service mission.

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Employment with the University will require successful completion of background check(s) in accordance with University policies.

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Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact 814-865-1473.

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