What are the responsibilities and job description for the Scientist - Cell-Based Assay Development & Execution position at The Steely Group?
Responsibilities :
The development and optimization of novel cell-based assays ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets
Design and implement laboratory experiments, generate & interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents
Design, implement, and optimize gene-editing workflows in a manner that enables development and evaluation of cell-based functional assays supporting therapeutic target screening or lead optimization studies
Learn, apply, and incorporate automation solutions during assay development, assay troubleshooting, mechanism-of-action studies, data analysis, and reporting
Investigate, identify, develop, and optimize new methods / techniques to generate reliable and reproducible data promptly
Semi-independently plan and implement experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem resolution skills
Maintain proficiency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in group discussions
Show excellent collaboration and communication skills as this role requires an ability to work closely with other scientists in the group and across the company
Adherence to good laboratory conduct, documentation practices, and safety guidelines Basic Qualifications :
0 Years w / Relevant PhD or equivalent (where applicable) 2 Years w / Relevant MS or equivalent 4 Years w / Relevant BS or equivalent Advanced and proficient understanding and use of technical principles, theories, and concepts to perform expansive range of work in a role. Basic knowledge of related and adjacent disciplinary areas. Preferred Qualifications :
Ph.D. degree or a master’s degree with 5 years postgraduate experience in cell and / or molecular biology or closely related field
Experience working as part of a multi-disciplinary team in a biopharmaceutical setting
Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays (e.g., TR-FRET, BRET, AlphaLISA, HCS, luminescence and fluorescence-based reporter and / or label-free assays) with experience in the utilization of lab automation across assay development and screening
Track record of developing, implementing, and performing novel cell-based screening assays in microtiter plates to support early drug discovery research
Ability to design and implement gene editing (CRISPR knock out / in) workflows enabling the development of targets specific and disease-relevant cell-based assays
Capacity to identify, evaluate, implement, and become proficient in novel laboratory techniques
Ability to create and establish priorities, manage work plans, and meet timeline
A flexible approach with strong interpersonal, communication and problem-solving skills
Demonstrated initiative, teamwork, collaboration, and passion for developing technical expertise across assay development to routine execution
Familiarity with software and statistical platforms for the analysis of large data sets (e.g., Screener, Spotfire)
