Associate Director, Biology & Translational Research in Inflammation & Immunology

Triveni Bio is breaking new ground on the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine. We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) and directly impacts skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders. Our pipeline includes a bispecific antibody (TRIV-573) that targets kallikreins 5 and 7 and interleukin-13 (IL-13), combining a novel mechanism with a highly validated approach across I&I disorders; and a monoclonal antibody (TRIV-920) that targets trypsin 1 and 2, with strong potential to treat patients with hereditary pancreatitis, a disorder with significant unmet need.

Triveni Bio seeks a highly motivated and experienced Associate Director to join our team. In your role, you will provide scientific leadership and expertise in the experimental design, execution, and interpretation of translational biomarkers and mechanism of action (MOA) studies. This is an exciting opportunity to shape the scientific biomarker strategy across multiple indications, advancing therapeutics targeting novel disease pathways. If you are passionate about driving innovation in biotech and have a proven track record in translational research, we would love to hear from you.

Key responsibilities

• Function as the team lead for the Biology and Translational Research group providing scientific leadership and mentorship to team members

• Identify key scientific questions that need to be prioritized to execute Triveni Bio’s scientific strategy, including exploratory biomarkers

• Lead the experimental design, execution, and analyses of biomarkers and mechanism of action studies in animal models or primary human cellular and tissue systems to inform target biology and biomarker strategy across indications

• Collaborate with colleagues in Computational Biology and Translational Medicine to develop translational biomarkers and mechanism of action insights into overall drug development strategies

• Identify and implement novel platforms and techniques as well as disease-relevant cell-based assays and human tissue systems for mechanism of action studies and exploratory biomarker development

• Serve as a subject matter expert in target biology and therapeutic mechanism of action, represent Biology and Translational Research in cross-functional program teams

• Contribute to scientific literature through publications, presentations, and participation in professional conferences

Qualifications

• Ph.D. in immunology or a related discipline with 10 years of experience in the pharmaceutical or biotechnology industries, demonstrated history of leadership and scientific accomplishment in biomarker and translational sciences

• Experience with Immunology and Inflammation indications

• Experience managing and leading a research team

• Deep knowledge in leveraging animal models and primary human cellular/tissue-based systems for mechanism of action studies to inform biomarker discovery

• Proven track record in assay development for biomarker discovery, experienced in standard techniques for measuring RNA and proteins in biosamples including omics data generation and analysis; RNA-seq, Mass spectrometry, IHC, MSD, ELISA, flow-based assays and other molecular biology techniques

• Experience in managing collaborations with CROs, vendors, and other external organizations

• Excellent interpersonal skills, ability to work collaboratively with key stakeholders, contribute to scientific collaborations and teamwork

• Strategic, excellent leadership and organizational skills with the ability to thrive in a dynamic and fast-paced setting

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