What are the responsibilities and job description for the ASSOCIATE SCIENTIST/SCIENTIST, CELL THERAPY PROCESS DEVELOPMENT position at TScan Therapeutics?
Position Summary :
TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an Associate Scientist / Scientist, Cellular Process Development to drive innovative efforts in building clinical manufacturing processes for the company's novel TCR-engineered T cell therapy products. This role resides within the Process Development organization and will play a critical role in accomplishing TScan Therapeutics' mission. Key activities will include the development of cellular manufacturing processes and analytical support as needed, technology evaluations, process scale-up, optimization and characterization, IND-enabling activities, and technology transfer to clinical manufacturing, amongst others.
The ideal candidate will (i) have a strong background in cellular bioprocessing with an understanding of the cGMPs and guidance related to the manufacture of cell therapies; (ii) be skilled in evaluating and testing in-process analytics of engineered T cell products such as, live / dead assays, cell enumeration, and flow cytometry; (iii) be a steadfast problem solver who is energized by a fast-paced, lean and agile environment; and (iv) be a team player who can foster productive relationships with internal colleagues and with external partners.
Responsibilities :
- Develop, optimize and scale up robust cell manufacturing processes to support Regulatory filings and GMP manufacturing.
- Design and execute scale-down and full-scale process characterization studies in support of late-phase and commercialization of cellular manufacturing processes.
- Participate in project and team meetings to provide updates and enable data-driven decisions.
- Act as primary SME for internal and external process development and technology evaluation studies.
- Author and review internal technical documents to support regulatory submissions and manufacturing technology transfers.
- Collaborate closely with internal and external stakeholders.
Requirements :
About TScan :
TScan Therapeutics is a fully integrated, next-generation TCR-T cell therapy company. Founded in 2018, TScan's platform was developed by Stephen Elledge, Ph.D., and Tomasz Kula, Ph.D., at Brigham and Women's Hospital and Harvard Medical School. TScan's transformative platform enables rapid discovery of TCRs and targets for engineered T cell therapy. This technology is extremely versatile and is applicable across multiple therapeutic areas beyond cancers, including autoimmune disorders and infectious diseases.
Do YOU have the anatomy of a TScanner?
Our talented, compassionate, and intelligent team is what makes TScan a Top Place to Work (as ranked by The Boston Globe). Our state-of-the-art offices with over 70,000 square feet of premium lab space, including an internal GMP manufacturing suite, are an environment that supports innovation, camaraderie, and professionalism. We are passionate, fun, flexible, and team oriented. Sound like you? Apply today.
EEO Statement
TScan is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. TScan provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with TScan regarding a reasonable accommodation in connection with the hiring process and / or to perform the responsibilities of the position for which the applicant has applied, please contact the recruiter.
Recruitment & Staffing Agencies
TScan Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to TScan Therapeutics or its employees is strictly prohibited unless contacted directly by TScan Therapeutics' internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of TScan Therapeutics, and TScan Therapeutics will not owe any referral or other fees with respect thereto.
