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Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem Cells

University of California
San Francisco, CA Full Time
POSTED ON 1/16/2025
AVAILABLE BEFORE 3/28/2025

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Pre-Clinical Research : Engineering CD34 Hematopoietic Stem Cells

The full job description covers all associated skills, previous experience, and any qualifications that applicants are expected to have.

Pre-Clinical Research : Engineering CD34 Hematopoietic Stem Cells

Location : 3739 Balboa Street #1057, San Francisco, CA 94121, United States

Job Posted Date : July 23, 2024

Positions Available : Part-time, Postdoc, Volunteer

Population : Life Sciences

Our organization received funding and is conducting pre-clinical research in transplant medicine, focusing on genetic engineering techniques to improve organ transplant compatibility and reduce rejection. The intention of the pre-clinical trial is to get the results published in a scientific journal and evaluate implementation in transplant recipients.

We are specifically studying two potential pathways :

  • Deactivation of HLA genes in donor organs using CRISPR-Cas9 delivered via lentiviral vectors or electroporation.
  • Creating chimeric bone marrow via engineered CD34 cells.

Job Requirements :

Experience / Skills :

  • Gene knockout engineering using lentiviral vectors or electroporation and CRISPR-Cas9
  • Strong knowledge of the immune system
  • Good Laboratory Practice (GLP) standards with animal models
  • Research design and scientific investigation background
  • Preferred Experience :

  • Understanding of hematopoietic stem cell chimerism
  • Familiarity with FDA approval processes
  • Post-doctorate or PhD
  • How to Apply :

    Send email with resume to Austin@Cardioclone.com

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