Postdoctoral Fellow - MICRO Tse Lab

Department

SOM KC Department of Microbiology, Molecular Genetic and Immunology

Tse Lab

Position Title

Postdoctoral Fellow - MICRO Tse Lab

Job Family Group

Professional Staff

Job Description Summary

A postdoctoral position is available in the laboratory of Dr. Hubert Tse in the Department of Microbiology, Molecular Genetics, and Immunology at the University of Kansas Medical Center. Our research program seeks to increase our understanding of the immunological and molecular mechanisms involved in autoimmune dysregulation in Type 1 diabetes (T1D). Through the use of novel murine models of T1D, human translational studies, and innovative technologies including spatial transcriptomics, single cell RNA-sequencing, and induced-pluripotent stem cells, we are interested in determining how reactive oxygen species (ROS) synthesis contributes to innate immune responses and autoreactive T cell effector mechanisms involved in pancreatic ß-cell destruction. Additional research projects in the lab include the use of novel immunoprotection strategies to delay islet transplantation rejection and to define the role of insulin-producing ß-cells in T1D. We seek a motivated, creative, independent, and energetic applicant with excellent communication skills and organization. The laboratory uses immunological methods, molecular biology, cellular biochemistry, redox biology, murine models, imaging, and flow cytometry to discover and evaluate new mechanisms of autoimmune dysregulation. If interested, please send a letter describing your research experience/interest/future career aspirations, your CV, and contact information for three references.

Job Description

Key Roles and Responsibilities:

Research Overview: Work with PI/faculty mentor, to design and perform research in induced-pluripotent stem cell-derived macrophages to examine their ability to delay autoimmune responses. Perform islet transplantation studies in mouse models of T1D to define optimal transplant sites and the use of accessory cells/therapies to prolong islet engraftment/protection. Determine how antiviral responses trigger T1D and define genetic mechanisms involved in disease susceptibility.

• Perform spatial transcriptomics to increase our understanding of the role of ß-cells in Type 1 diabetes.
• Perform data analysis, prepare data for presentations (oral and written), write manuscripts and other research documents.
  
  

Postdoc Expectations: The Postdoc will be expected to complete research projects under the guidance of the faculty mentor, record and interpret the results of their experiments in an (electronic) laboratory notebook, prepare publication-quality manuscripts (including figures and tables) and publish in peer-reviewed literature.

• Read literature articles, develop new ideas, and assimilate the information into his/her project design/interpretation.
• Dissemination of studies: Interact on a regular basis with their faculty mentor and members of the laboratory to discuss experimental design and interpretation of results.
• Present research aims and findings at department seminars and at scientific meetings. Write and publish their results as first author in abstracts, manuscripts, and posters.
• Submit fellowship applications, as eligible, to bolster research funding and CV building for projects.
  
  

Compliance: Attend and maintain compliance on all orientation and training sessions designated by the University and the Department of Microbiology, understand and follow all assigned duties, and attend regularly scheduled research team meetings.

Required Qualifications

Education:

• PhD in Microbiology, Immunology, Biochemistry, Molecular Biology, or related field
  
  

Experience

• Four (4) years of related research experience.
  
  

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. It is only a summary of the typical functions of the job, not an exhaustive list of all possible job responsibilities, tasks, duties, and assignments. Furthermore, job duties, responsibilities and activities may change at any time with or without notice.

Required Documents

• Resume/CV
• Cover Letter
  
  

Comprehensive Benefits Package

Coverage begins on day one for health, dental, and vision insurance and includes health expense accounts with generous employer contributions if the employee participates in a qualifying health plan. Employer-paid life insurance, long-term disability insurance, and various additional voluntary insurance plans are available. Paid time off, including vacation and sick, begins accruing upon hire, plus ten paid holidays. One paid discretionary day is available after six months of employment, and paid time off for bereavement, jury duty, military service, and parental leave is available after 12 months of employment. A retirement program with a generous employer contribution and additional voluntary retirement programs (457 or 403b) are available. https://www.kumc.edu/human-resources/benefits.html

Employee Type

Regular

Time Type

Full time

Rate Type

Salary

Compensation Statement

The pay range listed for this position is determined by our compensation program using market data and salary benchmarking. A combination of factors is considered in making compensation decisions including, but not limited to, education, experience and training, qualifications relative to the requirements of the position, and funding. At the University of Kansas Medical Center, a reasonable estimate for the starting pay range will be the minimum to midpoint of the posted range, taking into account the combination of factors listed above.

Pay Range

$58,656.00 - $80,000.00

Minimum

$58,656.00

Midpoint

$69,328.00

Maximum

$80,000.00