Duration : 12 months (Potential for extension)
Description :
Top three "Must Haves"
Lab experience in formulation of siRNA or oligonucleotides for systemic delivery
- Hands on Analytical characterization of oligonucleotides
- Experience in project management and collaborating with external CMO’s.
Job Description :
The Research Scientist RNAi formulations and Biophysics will be based in GNAT Research. The Research Scientist s a lab based role with hands on formulation, biophysical and analytical characterization expertise of oligonucleotides for injectable delivery.
Responsibilities :
As a Sr Sci I in the Nucleic Acid Delivery, Formulations & Bioanalysis overall department, you will become a part of a multinational and diverse team consisting of Reseach Associates, Specialist / Scientists. The goal of the team is to develop preclinical formulations of conjugated oligonucleotides apply advanced analytical characterization techniques and translate these to preclinical and clinical studies through internal and external collaborations in an automated high throughput manner.Identifies gaps in technological capabilities provides recommendations to guide the research agendaManage multiple external collaborations for deliverablesOptimize long-term storage and stability conditions of RNAi conjugates and oligonucleotide formulations in generalDevelop robust analytical methods and assays for QC and developability assessmentsCommunicate findings internally to team via presentations and written reportsAbility to thrive in a multi-disciplinary and fast-paced research environment with tight deadlinesQualifications
3 years of relevant experience with a PHD (LEVEL II) or 3 years of relevant experience with a Masters (LEVEL I)Subject matter expertise in Pharmaceutical Sciences, oligonucleotide / peptide / antibody characterisation, or related scientific disciplinesIn-depth and hands-on experience in a range of synthesis, characterization, and purification techniques, including but not limited to NMR, HPLC (analytical and preparative), Mass Spectrometry, IR, silica gel and reverse phase chromatography, TLC, recrystallization etc.Acting as formulation subject matter expert for nucleic acid therapeutics.Ability to establish screening assays for oligonucleotides in early discovery.Experience with analytical method development for solubility, viscosity, degradation and rheological assessment for complex olionucleotidesExperience with high-throughput screening methods such as DoE for optimizing formulations is a plusExcellent verbal communication and interpersonal skillsDemonstrate awareness of external trends, influences, and advances in the landscape of RNA delivery and clinical translationExperience with automation is considered an advantageProven track record in publishing in HQ / HI journals on relevant topics.Education :
Master’s Degree RequiredSkills :
Oligonucleotides ,Formulation , HPLC , Mass Spectrometry
About US Tech Solutions :
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details : Name : Aishwarya
Email : aishwarya.t@ustechsolutionsinc.com
Internal Id : 25-29102
